A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy
Abstract
1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Solubility
2.3. Cell Viability
2.4. Boron Uptake
3. Materials and Methods
3.1. Chemistry
3.2. Solubility Assessment via LC-MS/MS
3.3. Viability Tests
3.4. Boron Concentration Measurements
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | Treatment Protocol | 10B Concentration [ppm] | Uncertainty [ppm] |
---|---|---|---|
Control | - | 0 | 1 |
Sample 1 | 3.8 ppm 4 h | 1 | 1 |
Sample 2 | 3.8 ppm 4 h | 1 | 1 |
Sample 3 | 38 ppm 4 h | 21.2 | 0.3 |
Sample 4 | 38 ppm 4 h | 23.4 | 0.3 |
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Imperio, D.; Postuma, I.; Villani, S.; Del Grosso, E.; Cansolino, L.; Ferrari, C.; Fallarini, S.; Bortolussi, S.; Panza, L. A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy. Pharmaceuticals 2025, 18, 986. https://doi.org/10.3390/ph18070986
Imperio D, Postuma I, Villani S, Del Grosso E, Cansolino L, Ferrari C, Fallarini S, Bortolussi S, Panza L. A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy. Pharmaceuticals. 2025; 18(7):986. https://doi.org/10.3390/ph18070986
Chicago/Turabian StyleImperio, Daniela, Ian Postuma, Salvatore Villani, Erika Del Grosso, Laura Cansolino, Cinzia Ferrari, Silvia Fallarini, Silva Bortolussi, and Luigi Panza. 2025. "A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy" Pharmaceuticals 18, no. 7: 986. https://doi.org/10.3390/ph18070986
APA StyleImperio, D., Postuma, I., Villani, S., Del Grosso, E., Cansolino, L., Ferrari, C., Fallarini, S., Bortolussi, S., & Panza, L. (2025). A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy. Pharmaceuticals, 18(7), 986. https://doi.org/10.3390/ph18070986