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Volume 18
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10.3390/ph18040546
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Article

1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity

by
Anna Merwid-Ląd
1,*,
Piotr Ziółkowski
2,
Beata Nowak
1,
Piotr Świątek
3,
Łukasz Szczukowski
3,
Joanna Kwiatkowska
1,
Katarzyna Piasecka
1,
Adam Szeląg
1 and
Marta Szandruk-Bender
1
1
Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
2
Department of Clinical and Experimental Pathology, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wrocław, Poland
3
Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2025, 18(4), 546; https://doi.org/10.3390/ph18040546
Submission received: 4 March 2025 / Revised: 26 March 2025 / Accepted: 4 April 2025 / Published: 8 April 2025
(This article belongs to the Special Issue Recent Advances in the Discovery and Development of Drugs for Civilization Diseases)
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Abstract

Background/Objectives: Inflammatory bowel disease significantly impairs the patient’s quality of life. In young individuals, both the disease and the drugs used for the treatment may impact fertility. Our study aimed to assess the action of new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone on the rat testes in a model of TNBS-induced colitis in rats. Methods: In the current study, testes from eight randomly chosen rats were taken from each of the following groups: the control group (K), the colitis group (C), and the groups receiving compounds 7b, 10b, and 13b in higher doses (20 mg/kg). Results: Colitis did not affect the testicular index (expressed as a percentage of the body weight), but in group 13b, this parameter was significantly higher than in group K. No significant differences between groups were noticed in malondialdehyde, superoxide dismutase, interleukin-1, or metalloproteinase 9 levels. In the colitis group, lactate dehydrogenase activity in the testes was not increased; however, the administration of compound 10b significantly increased this parameter when compared to both groups K and C. Histological evaluation also did not reveal abnormalities, and the morphology of the testicular tissues was comparable in all groups. Conclusions: The results may suggest that the new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone did not exert significant testicular toxicity.
Keywords: testicular toxicity; experimental colitis; 1,3,4-oxadiazole; pyrrolo[3,4-d]pyridazinone derivatives; MDA; SOD; LDH; IL-1; MMP-9; histology testicular toxicity; experimental colitis; 1,3,4-oxadiazole; pyrrolo[3,4-d]pyridazinone derivatives; MDA; SOD; LDH; IL-1; MMP-9; histology

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MDPI and ACS Style

Merwid-Ląd, A.; Ziółkowski, P.; Nowak, B.; Świątek, P.; Szczukowski, Ł.; Kwiatkowska, J.; Piasecka, K.; Szeląg, A.; Szandruk-Bender, M. 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity. Pharmaceuticals 2025, 18, 546. https://doi.org/10.3390/ph18040546

AMA Style

Merwid-Ląd A, Ziółkowski P, Nowak B, Świątek P, Szczukowski Ł, Kwiatkowska J, Piasecka K, Szeląg A, Szandruk-Bender M. 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity. Pharmaceuticals. 2025; 18(4):546. https://doi.org/10.3390/ph18040546

Chicago/Turabian Style

Merwid-Ląd, Anna, Piotr Ziółkowski, Beata Nowak, Piotr Świątek, Łukasz Szczukowski, Joanna Kwiatkowska, Katarzyna Piasecka, Adam Szeląg, and Marta Szandruk-Bender. 2025. "1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity" Pharmaceuticals 18, no. 4: 546. https://doi.org/10.3390/ph18040546

APA Style

Merwid-Ląd, A., Ziółkowski, P., Nowak, B., Świątek, P., Szczukowski, Ł., Kwiatkowska, J., Piasecka, K., Szeląg, A., & Szandruk-Bender, M. (2025). 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity. Pharmaceuticals, 18(4), 546. https://doi.org/10.3390/ph18040546

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