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Pharmaceuticals
Volume 17
Issue 9
10.3390/ph17091222
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Article

Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin–Piperacillin/Tazobactam Incompatibility

by
Laura Négrier
1,
Bertrand Décaudin
1,
Anthony Treizebré
2,
Marie Guilbert
2,
Pascal Odou
1 and
Anthony Martin Mena
1,*
1
University of Lille, CHU Lille, ULR 7365—GRITA—Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France
2
University of Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520—IEMN—Institut d’Electronique de Microélectronique et de Nanotechnologie, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(9), 1222; https://doi.org/10.3390/ph17091222
Submission received: 23 July 2024 / Revised: 5 September 2024 / Accepted: 13 September 2024 / Published: 17 September 2024
(This article belongs to the Special Issue Pharmaceutical Preparations, Challenges in Formulations and Compatibility Studies)
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Abstract

Introduction: Drug incompatibilities are among the most common medication errors in intensive care units. A precipitate can form and block the catheter or cause an adverse event in the patient. Intensive care units have implemented various strategies for limiting the occurrence of these incompatibilities, which have already been studied in vitro under standardized conditions. The objective of the present in vitro study was to continue these assessments by determining the impact of the infusion line geometry and the drugs’ position in the infusion set-up on the prevention of vancomycin–piperacillin/tazobactam incompatibility. Methods: Infusion lines with a different common volume, a multilumen medical infusion device, a dilute vancomycin solution, and separate infusions of incompatible drugs were evaluated separately. The infusion line outlet was connected to a dynamic particle counter. Results: Reducing the common volume, using multilumen medical devices, or spacing out the two incompatible drugs on the infusion line did not prevent the occurrence of a significant particulate load. Only dilution of the vancomycin solution was associated with a significantly lower particulate load and the absence of drug incompatibility. Conclusions: Our results show that under specific conditions, it is possible to reduce particulate contamination considerably.
Keywords: vancomycin; piperacillin/tazobactam; drug incompatibility; infusion; particulate load; common volume; multilumen device vancomycin; piperacillin/tazobactam; drug incompatibility; infusion; particulate load; common volume; multilumen device
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MDPI and ACS Style

Négrier, L.; Décaudin, B.; Treizebré, A.; Guilbert, M.; Odou, P.; Martin Mena, A. Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin–Piperacillin/Tazobactam Incompatibility. Pharmaceuticals 2024, 17, 1222. https://doi.org/10.3390/ph17091222

AMA Style

Négrier L, Décaudin B, Treizebré A, Guilbert M, Odou P, Martin Mena A. Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin–Piperacillin/Tazobactam Incompatibility. Pharmaceuticals. 2024; 17(9):1222. https://doi.org/10.3390/ph17091222

Chicago/Turabian Style

Négrier, Laura, Bertrand Décaudin, Anthony Treizebré, Marie Guilbert, Pascal Odou, and Anthony Martin Mena. 2024. "Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin–Piperacillin/Tazobactam Incompatibility" Pharmaceuticals 17, no. 9: 1222. https://doi.org/10.3390/ph17091222

APA Style

Négrier, L., Décaudin, B., Treizebré, A., Guilbert, M., Odou, P., & Martin Mena, A. (2024). Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin–Piperacillin/Tazobactam Incompatibility. Pharmaceuticals, 17(9), 1222. https://doi.org/10.3390/ph17091222

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