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Pharmaceuticals
Volume 17
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10.3390/ph17081087
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Article

A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study

by
In-Kyung Jeong
1,*,†,
Anna Han
2,3,†,
Ji Eun Jun
1,
You-Cheol Hwang
1,
Kyu Jeung Ahn
1,
Ho Yeon Chung
1,
Bo Seung Kang
4 and
Se-Young Choung
5,6,*
1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Republic of Korea
2
Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea
3
K-Food Research Center, Jeonbuk National University, Jeonju 54896, Republic of Korea
4
Department of Emergency Medicine, Hanyang University Guri Hospital, Hangyang University College of Medicine, Guri 11923, Republic of Korea
5
Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Republic of Korea
6
Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2024, 17(8), 1087; https://doi.org/10.3390/ph17081087
Submission received: 19 July 2024 / Revised: 9 August 2024 / Accepted: 11 August 2024 / Published: 20 August 2024
(This article belongs to the Special Issue Discovery, Metabolism and Potential Bio-Activities of Natural Products in Traditional Medicine 2024)
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Abstract

This open-labeled and comparative study aimed to test the efficacy and safety of a fermented rice extract-based substance containing yeast-fermented powder having aldehyde dehydrogenase (KisLip®, Pico Entech, Republic of Korea) in healthy male individuals. Healthy male subjects (n = 20) consumed 90 g of alcohol at their first visit. At the second visit, participants consumed 90 g of alcohol or alcohol with a low dose of KISLip® (2000 mg, KL-L) and then 90 g of alcohol or alcohol with a high dose of KISLip® (3000 mg, KL-H) at the third visit. The efficacy of KISLip® depends on the mutational status of important genes related to alcohol metabolism, including alcohol dehydrogenase (ADH1B), cytochrome P4502E1 (CYP2E1 (5B) and CYP2E1 (6)), and aldehyde dehydrogenase (ALDH2). KISLip® significantly reduced the highest level (Cmax) of alcohol and overall levels of acetaldehyde compared to the alcohol-only group in a dose-dependent manner. These significant effects of KISLip® on alcohol metabolism were observed independent of mutations in the four genes. In addition, hangover symptoms were significantly decreased in the KISLip® treated groups. During the study, the participants did not show any adverse events after KISLip® intake. This clinical study suggested that supplementation of KISLip® had beneficial effects on alcohol metabolism and might ameliorate the severity of hangovers without any adverse events.
Keywords: alcohol drinking; genetic polymorphism; alcohol dehydrogenase; aldehyde dehydrogenase alcohol drinking; genetic polymorphism; alcohol dehydrogenase; aldehyde dehydrogenase

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MDPI and ACS Style

Jeong, I.-K.; Han, A.; Jun, J.E.; Hwang, Y.-C.; Ahn, K.J.; Chung, H.Y.; Kang, B.S.; Choung, S.-Y. A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study. Pharmaceuticals 2024, 17, 1087. https://doi.org/10.3390/ph17081087

AMA Style

Jeong I-K, Han A, Jun JE, Hwang Y-C, Ahn KJ, Chung HY, Kang BS, Choung S-Y. A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study. Pharmaceuticals. 2024; 17(8):1087. https://doi.org/10.3390/ph17081087

Chicago/Turabian Style

Jeong, In-Kyung, Anna Han, Ji Eun Jun, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, Bo Seung Kang, and Se-Young Choung. 2024. "A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study" Pharmaceuticals 17, no. 8: 1087. https://doi.org/10.3390/ph17081087

APA Style

Jeong, I.-K., Han, A., Jun, J. E., Hwang, Y.-C., Ahn, K. J., Chung, H. Y., Kang, B. S., & Choung, S.-Y. (2024). A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study. Pharmaceuticals, 17(8), 1087. https://doi.org/10.3390/ph17081087

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