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Review

Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review

by
Salem Bajramagic
1,2,
Marko Sever
1,3,
Fran Rasic
1,
Mario Staresinic
1,3,
Anita Skrtic
4,*,
Lidija Beketic Oreskovic
1,
Ivana Oreskovic
1,
Sanja Strbe
1,
Svjetlana Loga Zec
5,
Josip Hrabar
1,6,
Luka Coric
1,
Matea Prenc
1,6,
Vladimir Blagaic
1,
Klara Brcic
1,
Alenka Boban Blagaic
1,
Sven Seiwerth
4 and
Predrag Sikiric
2,*
1
Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
2
Clinic of General and Abdominal Surgery, Clinical Center University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
3
Department of Surgery, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
4
Department of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
5
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
6
Department of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(8), 1081; https://doi.org/10.3390/ph17081081
Submission received: 5 May 2024 / Revised: 28 July 2024 / Accepted: 14 August 2024 / Published: 17 August 2024
(This article belongs to the Special Issue Naturally Occurring Peptides and Proteins and Related Drugs)
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Abstract

By introducing the healing of many distinctive anastomoses by BPC 157 therapy, this review practically deals with the concept of the resection and reconnection of the hollow parts of the gastrointestinal tract as one of the cornerstones of visceral surgery. In principle, the healing of quite distinctive anastomoses itself speaks for applied BPC 157 therapy, in particular, as a way in which the therapy of anastomoses can be successfully approached and carried out. Some of the anastomoses implicated were esophagogastric, colocolonic, jejunoileal, and ileoileal anastomoses, along with concomitant disturbances, such as esophagitis, sphincter dysfunction, failed intestinal adaptation, colitis, short bowel syndrome, major vessel occlusion, NO-system, and prostaglandins-system dysfunction, which were accordingly counteracted as well, and, finally, findings concerning other anastomoses healing (i.e., nerve and vessel). Moreover, the healing of fistulas, both external and internal, colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, colovesical, and rectovaginal in rats, perceived as anastomoses made between two different tissues which are normally not connected, may also be indicative. This may be a particular reconnection of the parts of the gastrointestinal tract to re-establish adequate integrity depending on the tissue involved, given that both various intestinal anastomoses and various fistulas (intestinal and skin were accordingly healed simultaneously as the fistulas disappeared) were all healed.
Keywords: stable gastric pentadecapeptide BPC 157; esophagogastric, colocolonic, jejunoileal, and ileoileal anastomoses; short bowel; rats; therapy stable gastric pentadecapeptide BPC 157; esophagogastric, colocolonic, jejunoileal, and ileoileal anastomoses; short bowel; rats; therapy

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MDPI and ACS Style

Bajramagic, S.; Sever, M.; Rasic, F.; Staresinic, M.; Skrtic, A.; Beketic Oreskovic, L.; Oreskovic, I.; Strbe, S.; Loga Zec, S.; Hrabar, J.; et al. Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review. Pharmaceuticals 2024, 17, 1081. https://doi.org/10.3390/ph17081081

AMA Style

Bajramagic S, Sever M, Rasic F, Staresinic M, Skrtic A, Beketic Oreskovic L, Oreskovic I, Strbe S, Loga Zec S, Hrabar J, et al. Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review. Pharmaceuticals. 2024; 17(8):1081. https://doi.org/10.3390/ph17081081

Chicago/Turabian Style

Bajramagic, Salem, Marko Sever, Fran Rasic, Mario Staresinic, Anita Skrtic, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Svjetlana Loga Zec, Josip Hrabar, and et al. 2024. "Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review" Pharmaceuticals 17, no. 8: 1081. https://doi.org/10.3390/ph17081081

APA Style

Bajramagic, S., Sever, M., Rasic, F., Staresinic, M., Skrtic, A., Beketic Oreskovic, L., Oreskovic, I., Strbe, S., Loga Zec, S., Hrabar, J., Coric, L., Prenc, M., Blagaic, V., Brcic, K., Boban Blagaic, A., Seiwerth, S., & Sikiric, P. (2024). Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review. Pharmaceuticals, 17(8), 1081. https://doi.org/10.3390/ph17081081

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