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Volume 17
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10.3390/ph17030401
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Article

The Potential Role of the Extracellular Matrix Glycoprotein Reelin in Glioblastoma Biology

by
Erika Ongemach
1,2,
Daniela Zerrinius
2,
Philipp Heimann
1,2,
Christian Rainer Wirtz
3,
Klaus-Michael Debatin
1,
Mike-Andrew Westhoff
1,*,† and
Aurelia Peraud
2,*,†
1
Department of Pediatrics and Adolescent Medicine, Ulm University Hospital, 89075 Ulm, Germany
2
Division Pediatric Neurosurgery, Department of Neurosurgery, Ulm University Hospital, 89081 Ulm, Germany
3
Department of Neurosurgery, Ulm University Hospital, 89081 Ulm, Germany
*
Authors to whom correspondence should be addressed.
†
These authors have contributed equally to this work.
Pharmaceuticals 2024, 17(3), 401; https://doi.org/10.3390/ph17030401
Submission received: 6 February 2024 / Revised: 10 March 2024 / Accepted: 15 March 2024 / Published: 21 March 2024
(This article belongs to the Special Issue The 20th Anniversary of Pharmaceuticals—Emerging Trends in Biopharmaceuticals)
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Abstract

Glioblastoma, the most common and lethal primary adult brain tumor, cannot be successfully removed surgically due to its highly invasive nature. Therapeutically, approaches must be aimed at a systemic brain disease and not merely at a tumor located within the brain, unless a successful containment strategy can be found. Reelin, an extracellular matrix glycoprotein, plays an important role in neuronal migration and serves here as a natural stop signal. Interestingly, the expression of reelin is negatively associated with tumor grade and, within glioblastoma, correlates with increased overall survival. To further elucidate a potential biological reason for these findings, we looked at the cellular behavior of glioblastoma cell lines grown on a pure fibronectin matrix or a matrix with reelin inserts. While reelin had no significant effects on cellular metabolism, proliferation, or resistance to chemotherapeutic agents, it did significantly affect the cells’ interaction with fibronectin. Both matrix attachment and detachment were modulated by reelin, and thus, the invasion and motility of cells interacting with a reelin-containing matrix were altered. The data presented in this work strongly suggest that reelin might be a potential modulator of underlying molecular mechanisms that contribute to glioblastoma invasion.
Keywords: fibronectin; glioblastoma; motility; invasion; reelin; extracellular matrix fibronectin; glioblastoma; motility; invasion; reelin; extracellular matrix

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MDPI and ACS Style

Ongemach, E.; Zerrinius, D.; Heimann, P.; Wirtz, C.R.; Debatin, K.-M.; Westhoff, M.-A.; Peraud, A. The Potential Role of the Extracellular Matrix Glycoprotein Reelin in Glioblastoma Biology. Pharmaceuticals 2024, 17, 401. https://doi.org/10.3390/ph17030401

AMA Style

Ongemach E, Zerrinius D, Heimann P, Wirtz CR, Debatin K-M, Westhoff M-A, Peraud A. The Potential Role of the Extracellular Matrix Glycoprotein Reelin in Glioblastoma Biology. Pharmaceuticals. 2024; 17(3):401. https://doi.org/10.3390/ph17030401

Chicago/Turabian Style

Ongemach, Erika, Daniela Zerrinius, Philipp Heimann, Christian Rainer Wirtz, Klaus-Michael Debatin, Mike-Andrew Westhoff, and Aurelia Peraud. 2024. "The Potential Role of the Extracellular Matrix Glycoprotein Reelin in Glioblastoma Biology" Pharmaceuticals 17, no. 3: 401. https://doi.org/10.3390/ph17030401

APA Style

Ongemach, E., Zerrinius, D., Heimann, P., Wirtz, C. R., Debatin, K.-M., Westhoff, M.-A., & Peraud, A. (2024). The Potential Role of the Extracellular Matrix Glycoprotein Reelin in Glioblastoma Biology. Pharmaceuticals, 17(3), 401. https://doi.org/10.3390/ph17030401

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