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Volume 16
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10.3390/ph16010038
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Article

Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats

by
Adel Al Fatease
1,
Mohammed A. S. Abourehab
2,3,
Ali M. Alqahtani
4,
Kumarappan Chidambaram
4,
Absar Ahmed Qureshi
4,
Krishnaraju Venkatesan
4,
Sultan M. Alshahrani
5 and
Hamdy Abdelkader
1,2,*
1
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
2
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
3
Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia
4
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
5
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(1), 38; https://doi.org/10.3390/ph16010038
Submission received: 14 November 2022 / Revised: 21 December 2022 / Accepted: 22 December 2022 / Published: 27 December 2022
(This article belongs to the Section Pharmaceutical Technology)
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Abstract

Curcumin is the main active constituent in turmeric, and it is one of the biopolyphenolic compounds. A cumulative body of research supports the use of curcumin in the treatment of wounds, yet poor water solubility and lack of therapeutic dose determination hamper its use for this therapeutic purpose. This work aimed at preparing novel curcumin wafer dressings to provide a favorable environment for wound healing. Hybrid synthetic (PVA, PVP, HPMC, and CMC) and biodegradable (sodium alginate and dextran) polymers were employed to prepare wafer dressings loaded with incremental three doses (2, 10, and 20 mg) of curcumin per a wafer dressing. The solvent casting method was used to prepare the dressings. Dimension, surface pH, mechanical properties, DSC, FTIR, XRD, erosion time, and in vitro release were studied. Skin wound healing assay was studied in Wistar albino rats. Six curcumin-loaded wafers were successfully prepared with good mechanical properties. Curcumin was dispersed in an amorphous/molecular form, as evidenced by thermal (DSC) and spectral (FTIR and XRD) analyses. Prolonged curcumin release (>24 h) was recorded for F6 (10 mg curcumin) and F7 (20 mg curcumin). Wound healing rate constants and time for 50% wound closure (T1/2) were estimated from a semi-log wound diameter versus time curve. A superior healing rate (up to 3-fold faster) was recorded for curcumin-loaded wafer dressings containing 10 mg (F6) with T1/2 of 7 days compared to 20 days for the placebo-treated group. These results warrant using the selected curcumin-loaded wafer dressing for safer and faster wound closure.
Keywords: curcumin; dextran; wafer; wound; alginate; dressing curcumin; dextran; wafer; wound; alginate; dressing

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MDPI and ACS Style

Al Fatease, A.; Abourehab, M.A.S.; Alqahtani, A.M.; Chidambaram, K.; Qureshi, A.A.; Venkatesan, K.; Alshahrani, S.M.; Abdelkader, H. Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats. Pharmaceuticals 2023, 16, 38. https://doi.org/10.3390/ph16010038

AMA Style

Al Fatease A, Abourehab MAS, Alqahtani AM, Chidambaram K, Qureshi AA, Venkatesan K, Alshahrani SM, Abdelkader H. Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats. Pharmaceuticals. 2023; 16(1):38. https://doi.org/10.3390/ph16010038

Chicago/Turabian Style

Al Fatease, Adel, Mohammed A. S. Abourehab, Ali M. Alqahtani, Kumarappan Chidambaram, Absar Ahmed Qureshi, Krishnaraju Venkatesan, Sultan M. Alshahrani, and Hamdy Abdelkader. 2023. "Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats" Pharmaceuticals 16, no. 1: 38. https://doi.org/10.3390/ph16010038

APA Style

Al Fatease, A., Abourehab, M. A. S., Alqahtani, A. M., Chidambaram, K., Qureshi, A. A., Venkatesan, K., Alshahrani, S. M., & Abdelkader, H. (2023). Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats. Pharmaceuticals, 16(1), 38. https://doi.org/10.3390/ph16010038

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