Next Article in Journal
Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Next Article in Special Issue
Dihydroconiferyl Ferulate Isolated from Dendropanax morbiferus H.Lév. Suppresses Stemness of Breast Cancer Cells via Nuclear EGFR/c-Myc Signaling
Previous Article in Journal
A Robust and Fast/Multiplex Pharmacogenetics Assay to Simultaneously Analyze 17 Clinically Relevant Genetic Polymorphisms in CYP3A4, CYP3A5, CYP1A2, CYP2C9, CYP2C19, CYP2D6, ABCB1, and VKORC1 Genes
Previous Article in Special Issue
Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis
 
 
Article

Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries

1
Laboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
3
Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3000-548 Coimbra, Portugal
4
Centre of Cardiothoracic Surgery, University Hospital and Faculty of Medicine of Coimbra, 3000-075 Coimbra, Portugal
5
Clinical Academic Centre of Coimbra, CACC, 3000-075 Coimbra, Portugal
6
Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
7
REQUIMTE/LAQV, R. D. Manuel II, Apartado 55142, 4051-401 Oporto, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editors: Víctor López and Filippo Maggi
Pharmaceuticals 2022, 15(5), 638; https://doi.org/10.3390/ph15050638
Received: 29 April 2022 / Revised: 11 May 2022 / Accepted: 18 May 2022 / Published: 22 May 2022
Agrimonia eupatoria L. has been traditionally used for the treatment of inflammatory diseases but also as a hypotensive. To our knowledge, only one study has previously suggested an improvement in vascular endothelial function in diabetic conditions, as the underlying mechanisms and responsible compounds are unknown. In this study, we aimed to assess the direct vascular effects of Agrimonia eupatoria L. in human arteries. The infusion elicited a mild increase in basal vascular tone and a significant potentiation of the adrenergic contraction of 49.18% at 0.02 mg/mL, suggesting the presence of compounds with mild vasoconstrictor activity. In contrast, the ethyl acetate fraction inhibited adrenergic contraction by 80.65% at 2 mg/mL and elicited no effect on basal vascular tone. A potent concentration-dependent vasorelaxation was observed for both the infusion and the ethyl acetate fraction (maximal relaxation above 76% and 47%, respectively). Inhibition of nitric oxide synthase and cyclooxygenase elicited significant decreases in the vasorelaxation to the infusion, as, for the ethyl acetate fraction, only the cyclooxygenase pathway appeared to be involved. Isoquercitrin elicited a vasoactivity consistent with the ethyl acetate fraction, suggesting this is a major component responsible for the vasorelaxant properties of A. eupatoria. Further research is warranted to fully evaluate its vasoprotective properties with therapeutic potential in several conditions, e.g., atherosclerosis. View Full-Text
Keywords: Agrimonia eupatoria L.; vasorelaxation; cyclooxygenase; nitric oxide; human internal thoracic artery; vasoprotective potential; polyphenols; isoquercitrin; quercetin Agrimonia eupatoria L.; vasorelaxation; cyclooxygenase; nitric oxide; human internal thoracic artery; vasoprotective potential; polyphenols; isoquercitrin; quercetin
Show Figures

Figure 1

MDPI and ACS Style

Malheiros, J.; Simões, D.M.; Antunes, P.E.; Figueirinha, A.; Cotrim, M.D.; Fonseca, D.A. Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries. Pharmaceuticals 2022, 15, 638. https://doi.org/10.3390/ph15050638

AMA Style

Malheiros J, Simões DM, Antunes PE, Figueirinha A, Cotrim MD, Fonseca DA. Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries. Pharmaceuticals. 2022; 15(5):638. https://doi.org/10.3390/ph15050638

Chicago/Turabian Style

Malheiros, Jéssica, Daniela M. Simões, Pedro E. Antunes, Artur Figueirinha, Maria Dulce Cotrim, and Diogo A. Fonseca. 2022. "Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries" Pharmaceuticals 15, no. 5: 638. https://doi.org/10.3390/ph15050638

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop