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Volume 15
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10.3390/ph15050609
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Systematic Review

Resveratrol and Curcumin for Chagas Disease Treatment—A Systematic Review

by
Carlos Henrique Lima Imperador
1,
Cauê Benito Scarim
2,
Priscila Longhin Bosquesi
1,2,
Juliana Romano Lopes
2,3,
Augusto Cardinalli Neto
1,4,
Jeanine Giarolla
5,
Elizabeth Igne Ferreira
5,
Jean Leandro dos Santos
2,3 and
Chung Man Chin
1,2,*
1
Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil
2
Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Araraquara 14800-903, SP, Brazil
3
Chemical Institute, University of São Paulo State (UNESP), Araraquara 14800-900, SP, Brazil
4
Faculdade de Medicina de São José do Rio Preto ( FAMERP), Sao Jose do Rio Preto 15090-000, SP, Brazil
5
Laboratory of Synthesis and Drug Design for Neglected Disease (LAPEN), School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo 05508-220, SP, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(5), 609; https://doi.org/10.3390/ph15050609
Submission received: 15 April 2022 / Revised: 3 May 2022 / Accepted: 9 May 2022 / Published: 15 May 2022
(This article belongs to the Special Issue Drug Candidates for the Treatment of Infectious Diseases)
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Abstract

Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi, which affects about 7 million people worldwide. There are two available drugs in therapeutics, however, they lack effectiveness for the chronic stage—characterized mainly by cardiac (i.e., cardiomyopathy) and digestive manifestations (i.e., megaesophagus, megacolon). Due to the involvement of the immuno-inflammatory pathways in the disease’s progress, compounds exhibiting antioxidant and anti-inflammatory activity seem to be effective for controlling some clinical manifestations, mainly in the chronic phase. Resveratrol (RVT) and curcumin (CUR) are natural compounds with potent antioxidant and anti-inflammatory properties and their cardioprotective effect have been proposed to have benefits to treat CD. Such effects could decrease or block the progression of the disease’s severity. The purpose of this systematic review is to analyze the effectiveness of RVT and CUR in animal and clinical research for the treatment of CD. The study was performed according to PRISMA guidelines and it was registered on PROSPERO (CDR42021293495). The results did not find any clinical study, and the animal research was analyzed according to the SYRCLES risk of bias tools and ARRIVE 2.0 guidelines. We found 9 eligible reports in this study. We also discuss the potential RVT and CUR derivatives for the treatment of CD as well.
Keywords: Chagas disease; Trypanosoma cruzi; resveratrol; curcumin; anti-inflammatory Chagas disease; Trypanosoma cruzi; resveratrol; curcumin; anti-inflammatory

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MDPI and ACS Style

Imperador, C.H.L.; Scarim, C.B.; Bosquesi, P.L.; Lopes, J.R.; Cardinalli Neto, A.; Giarolla, J.; Ferreira, E.I.; dos Santos, J.L.; Chin, C.M. Resveratrol and Curcumin for Chagas Disease Treatment—A Systematic Review. Pharmaceuticals 2022, 15, 609. https://doi.org/10.3390/ph15050609

AMA Style

Imperador CHL, Scarim CB, Bosquesi PL, Lopes JR, Cardinalli Neto A, Giarolla J, Ferreira EI, dos Santos JL, Chin CM. Resveratrol and Curcumin for Chagas Disease Treatment—A Systematic Review. Pharmaceuticals. 2022; 15(5):609. https://doi.org/10.3390/ph15050609

Chicago/Turabian Style

Imperador, Carlos Henrique Lima, Cauê Benito Scarim, Priscila Longhin Bosquesi, Juliana Romano Lopes, Augusto Cardinalli Neto, Jeanine Giarolla, Elizabeth Igne Ferreira, Jean Leandro dos Santos, and Chung Man Chin. 2022. "Resveratrol and Curcumin for Chagas Disease Treatment—A Systematic Review" Pharmaceuticals 15, no. 5: 609. https://doi.org/10.3390/ph15050609

APA Style

Imperador, C. H. L., Scarim, C. B., Bosquesi, P. L., Lopes, J. R., Cardinalli Neto, A., Giarolla, J., Ferreira, E. I., dos Santos, J. L., & Chin, C. M. (2022). Resveratrol and Curcumin for Chagas Disease Treatment—A Systematic Review. Pharmaceuticals, 15(5), 609. https://doi.org/10.3390/ph15050609

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