Next Article in Journal
Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)
Previous Article in Journal
A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 15
Issue 3
10.3390/ph15030272
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

by
Rameshwar S. Cheke
1,*,
Vaishali M. Patil
2,
Sandip D. Firke
3,
Jaya P. Ambhore
1,
Iqrar A. Ansari
3,
Harun M. Patel
3,
Sachin D. Shinde
4,
Visweswara Rao Pasupuleti
5,6,7,*,
Md Imtaiyaz Hassan
8,
Mohd Adnan
9,
Adel Kadri
10,11 and
Mejdi Snoussi
9,12
1
Department of Pharmaceutical Chemistry, Dr. Rajendra Gode College of Pharmacy, Malkapur 443101, Maharashtra, India
2
Department of Pharmaceutical Chemistry, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad 201206, Uttar Pradesh, India
3
Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra, India
4
Department of Pharmacology, Shri. R. D. Bhakt College of Pharmacy, Jalna 431213, Maharashtra, India
5
Department of Biomedical Sciences and Therapeutics, Faculty of Medicine & Health Sciences, University Malaysia Sabah, Kota Kinabalu 44800, Sabah, Malaysia
6
Department of Biochemistry, Faculty of Medicine and Health Sciences, Abdurrab University, Pekanbaru 28291, Riau, Indonesia
7
Centre for International Collaboration and Research, Reva University, Rukmini Knowledge Park, Kattigenahalli, Yelahanka, Bangalore 560064, Karnataka, India
8
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
9
Department of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Ha′il 2440, Saudi Arabia
10
Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, Sfax 3000, Tunisia
11
Faculty of Science and Arts in Baljurashi, Albaha University, P.O. Box 1988, Albaha 65527, Saudi Arabia
12
Laboratory of Genetics, Biodiversity and Valorization of Bio-Resources (LR11ES41), University of Monastir, Higher Institute of Biotechnology of Monastir, Avenue Tahar Haddad, BP74, Monastir 5000, Tunisia
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(3), 272; https://doi.org/10.3390/ph15030272
Submission received: 20 December 2021 / Revised: 29 January 2022 / Accepted: 30 January 2022 / Published: 22 February 2022
(This article belongs to the Section Natural Products)
Browse Figures
Versions Notes

Abstract

Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, anticonvulsant, anti-HIV, and so on. Many research chemists take advantage of the gentle structure of isatins, such as NH at position 1 and carbonyl functions at positions 2 and 3, for designing biologically active analogues via different approaches. Literature surveys based on reported preclinical, clinical, and patented details confirm the multitarget profile of isatin analogues and thus their importance in the field of medicinal chemistry as a potent chemotherapeutic agent. This review represents the recent development of isatin analogues possessing potential pharmacological action in the years 2016–2020. The structure–activity relationship is also discussed to provide a pharmacophoric pattern that may contribute in the future to the design and synthesis of potent and less toxic therapeutics.
Keywords: chemotherapeutic agent; anticancer drugs; isatin derivatives; drug design and development; heterocyclic compounds; therapeutic targeting chemotherapeutic agent; anticancer drugs; isatin derivatives; drug design and development; heterocyclic compounds; therapeutic targeting

Share and Cite

MDPI and ACS Style

Cheke, R.S.; Patil, V.M.; Firke, S.D.; Ambhore, J.P.; Ansari, I.A.; Patel, H.M.; Shinde, S.D.; Pasupuleti, V.R.; Hassan, M.I.; Adnan, M.; et al. Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery. Pharmaceuticals 2022, 15, 272. https://doi.org/10.3390/ph15030272

AMA Style

Cheke RS, Patil VM, Firke SD, Ambhore JP, Ansari IA, Patel HM, Shinde SD, Pasupuleti VR, Hassan MI, Adnan M, et al. Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery. Pharmaceuticals. 2022; 15(3):272. https://doi.org/10.3390/ph15030272

Chicago/Turabian Style

Cheke, Rameshwar S., Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, and et al. 2022. "Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery" Pharmaceuticals 15, no. 3: 272. https://doi.org/10.3390/ph15030272

APA Style

Cheke, R. S., Patil, V. M., Firke, S. D., Ambhore, J. P., Ansari, I. A., Patel, H. M., Shinde, S. D., Pasupuleti, V. R., Hassan, M. I., Adnan, M., Kadri, A., & Snoussi, M. (2022). Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery. Pharmaceuticals, 15(3), 272. https://doi.org/10.3390/ph15030272

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop