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Review

Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

1
Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany
2
Department of Microbiology, School of Medicine, University of Sevilla and Instituto de Biomedicina de Sevilla (IBIS), 41009 Sevilla, Spain
3
Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain
4
Department of Microbiology, Miguel Servet University Hospital, 50009 Zaragoza, Spain
5
Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, 50001 Zaragoza, Spain
6
Department of Dermatology, Miguel Servet University Hospital, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Serge Mordon
Pharmaceuticals 2021, 14(7), 603; https://doi.org/10.3390/ph14070603
Received: 15 May 2021 / Revised: 14 June 2021 / Accepted: 16 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Photodynamic Therapy 2021)
The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult. View Full-Text
Keywords: photoinactivation; resistance; antimicrobial agents; SSTI; MDR photoinactivation; resistance; antimicrobial agents; SSTI; MDR
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MDPI and ACS Style

Pérez-Laguna, V.; García-Luque, I.; Ballesta, S.; Rezusta, A.; Gilaberte, Y. Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances. Pharmaceuticals 2021, 14, 603. https://doi.org/10.3390/ph14070603

AMA Style

Pérez-Laguna V, García-Luque I, Ballesta S, Rezusta A, Gilaberte Y. Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances. Pharmaceuticals. 2021; 14(7):603. https://doi.org/10.3390/ph14070603

Chicago/Turabian Style

Pérez-Laguna, Vanesa, Isabel García-Luque, Sofía Ballesta, Antonio Rezusta, and Yolanda Gilaberte. 2021. "Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances" Pharmaceuticals 14, no. 7: 603. https://doi.org/10.3390/ph14070603

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