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The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

1
Department of Pathology, Wroclaw Medical University, 50-367 Wroclaw, Poland
2
Department of Biotechnology, Wroclaw University, 50-383 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Francois Dufrasne
Pharmaceuticals 2021, 14(4), 309; https://doi.org/10.3390/ph14040309
Received: 5 March 2021 / Revised: 26 March 2021 / Accepted: 29 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Drug Candidates for the Treatment of Immune Disease)
Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing inflammation. Immune cells including macrophages, lymphocytes, neutrophils, mast cells, natural killer cells, innate lymphoid cells, as well as synovial tissue cells, like fibroblast-like synoviocytes, chondrocytes, and osteoclasts secrete different proinflammatory factors, including many cytokines, angiogenesis-stimulating molecules and others. Recent studies reveal that curcumin, a natural dietary anti-inflammatory compound, can modulate the response of the cells engaging in RA course. This review comprises detailed data about the pathogenesis and inflammation process in rheumatoid arthritis and demonstrates scientific investigations about the molecular interactions between curcumin and immune cells responsible for rheumatoid arthritis development to discuss this herbal drug’s immunoregulatory role in RA treatment. View Full-Text
Keywords: rheumatoid arthritis; curcumin; immune cells; immunomodulation; autoimmune disease rheumatoid arthritis; curcumin; immune cells; immunomodulation; autoimmune disease
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MDPI and ACS Style

Makuch, S.; Więcek, K.; Woźniak, M. The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis. Pharmaceuticals 2021, 14, 309. https://doi.org/10.3390/ph14040309

AMA Style

Makuch S, Więcek K, Woźniak M. The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis. Pharmaceuticals. 2021; 14(4):309. https://doi.org/10.3390/ph14040309

Chicago/Turabian Style

Makuch, Sebastian, Kamil Więcek, and Marta Woźniak. 2021. "The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis" Pharmaceuticals 14, no. 4: 309. https://doi.org/10.3390/ph14040309

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