Next Article in Journal
Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies
Next Article in Special Issue
New Acyl Derivatives of 3-Aminofurazanes and Their Antiplasmodial Activities
Previous Article in Journal
Doxepin Exacerbates Renal Damage, Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Urinary Chromium Loss in Obese Mice
Previous Article in Special Issue
Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in Caenorhabditis elegans
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 14
Issue 3
10.3390/ph14030268
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae

by
Ignacio Fernández-Pastor
1,
Victor González-Menéndez
1,
Frederick Annang
1,
Clara Toro
1,
Thomas A. Mackenzie
1,
Cristina Bosch-Navarrete
2,
Olga Genilloud
1 and
Fernando Reyes
1,*
1
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores de Andalucía, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 34, 18016 Granada, Spain
2
Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(3), 268; https://doi.org/10.3390/ph14030268
Submission received: 22 February 2021 / Revised: 9 March 2021 / Accepted: 13 March 2021 / Published: 16 March 2021
(This article belongs to the Special Issue Antiparasitics)
Browse Figures
Review Reports Versions Notes

Abstract

A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land of Montefrío, Granada, Spain. The structure of this compound, including its absolute configuration, was elucidated by HRMS, 1-D and 2-D NMR spectroscopy, and Marfey’s analysis. This metabolite displayed interesting activity against Plasmodium falciparum and Trypanosoma cruzi, with IC50 values in the micromolar range, and no significant cytotoxicity against the human cancer cell lines A549, A2058, MCF7, MIA PaCa-2, and HepG2.
Keywords: pipecolisporin; Nigrospora oryzae; fungal endophyte; structural elucidation; Marfey’s analysis; antiparasitic activity pipecolisporin; Nigrospora oryzae; fungal endophyte; structural elucidation; Marfey’s analysis; antiparasitic activity

Share and Cite

MDPI and ACS Style

Fernández-Pastor, I.; González-Menéndez, V.; Annang, F.; Toro, C.; Mackenzie, T.A.; Bosch-Navarrete, C.; Genilloud, O.; Reyes, F. Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals 2021, 14, 268. https://doi.org/10.3390/ph14030268

AMA Style

Fernández-Pastor I, González-Menéndez V, Annang F, Toro C, Mackenzie TA, Bosch-Navarrete C, Genilloud O, Reyes F. Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals. 2021; 14(3):268. https://doi.org/10.3390/ph14030268

Chicago/Turabian Style

Fernández-Pastor, Ignacio, Victor González-Menéndez, Frederick Annang, Clara Toro, Thomas A. Mackenzie, Cristina Bosch-Navarrete, Olga Genilloud, and Fernando Reyes. 2021. "Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae" Pharmaceuticals 14, no. 3: 268. https://doi.org/10.3390/ph14030268

APA Style

Fernández-Pastor, I., González-Menéndez, V., Annang, F., Toro, C., Mackenzie, T. A., Bosch-Navarrete, C., Genilloud, O., & Reyes, F. (2021). Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals, 14(3), 268. https://doi.org/10.3390/ph14030268

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop