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Review

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander University Erlangen-Nürnberg (FAU), D-91054 Erlangen, Germany
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Academic Editor: Irina Velikyan
Pharmaceuticals 2021, 14(11), 1175; https://doi.org/10.3390/ph14111175
Received: 18 October 2021 / Revised: 11 November 2021 / Accepted: 15 November 2021 / Published: 17 November 2021
In the field of 18F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective 18F-labeling of biomolecules. Among those, chemoselective 18F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of 18F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various 18F-fluoroglycosylation methods that were developed and applied as of 2014 (Maschauer and Prante, BioMed. Res. Int. 2014, 214748). This paper is an updated review, providing the recent progress in 18F-fluoroglycosylation reactions and the preclinical application of 18F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins. View Full-Text
Keywords: fluorine-18; prosthetic group; 18F-fluoroglycosylation; positron emission tomography; PET fluorine-18; prosthetic group; 18F-fluoroglycosylation; positron emission tomography; PET
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MDPI and ACS Style

Shinde, S.S.; Maschauer, S.; Prante, O. Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects. Pharmaceuticals 2021, 14, 1175. https://doi.org/10.3390/ph14111175

AMA Style

Shinde SS, Maschauer S, Prante O. Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects. Pharmaceuticals. 2021; 14(11):1175. https://doi.org/10.3390/ph14111175

Chicago/Turabian Style

Shinde, Sandip S., Simone Maschauer, and Olaf Prante. 2021. "Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects" Pharmaceuticals 14, no. 11: 1175. https://doi.org/10.3390/ph14111175

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