Next Article in Journal
Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells
Previous Article in Journal
Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
Review

Recent Advances Regarding the Therapeutic Potential of Adapalene

1
Pharmaceutical and Therapeutical Chemistry Department, Faculty of Pharmacy, George Emil Palade, University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, 540139 Târgu Mureş, Romania
2
Pharmaceutical Botany Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, 540139 Târgu Mureş, Romania
3
Gedeon Richter Romania, 540139 Târgu Mureş, Romania
4
Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, 540139 Târgu Mureş, Romania
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(9), 217; https://doi.org/10.3390/ph13090217
Received: 11 August 2020 / Revised: 26 August 2020 / Accepted: 26 August 2020 / Published: 28 August 2020
(This article belongs to the Section Medicinal Chemistry)
Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors. The comedolytic, anti-inflammatory, antiproliferative, and immunomodulatory are the known ADP effects. Its safety profile is an advantage over other retinoids. ADP recently was found to be effective in the treatment of several dermatological diseases and photoaging besides the utility in the treatment of acne vulgaris. New biological effects of adapalene with therapeutic potential are highlighted in this review paper. Thus, adapalene could be a valuable therapeutic drug into the treatment of several types of cancer. Additionally, some neurodegenerative diseases could be treated with a suitable formulation for intravenous administration. The antibacterial activity against methicillin-resistant Staphylococcus aureus of an analogue of ADP has been proven. In different therapeutic schemes, ADP is more effective in combination with other active substances. New topical combinations with adapalene include ketoconazole (antifungal), mometasone furoate (anti-inflammatory corticosteroid), nadifloxacin (fluoroquinolone), and alfa and beta hydroxy acids. Combination with oral drugs is a new trend that enhances the properties of topical formulations with adapalene. Several studies have investigated the effects of ADP in co-administration with azithromycin, doxycycline, faropenem, isotretinoin, and valganciclovir. Innovative formulations of ADP also aim to achieve a better bioavailability, increased efficacy, and reduced side effects. In this review, we have highlighted the current studies on adapalene regarding biological effects useful in various treatment types. Adapalene has not been exploited yet to its full biological potential. View Full-Text
Keywords: adapalene; dermatology; retinoids; cancer; antitumor effects; neuroprotection; antibacterial adapalene; dermatology; retinoids; cancer; antitumor effects; neuroprotection; antibacterial
Show Figures

Graphical abstract

MDPI and ACS Style

Rusu, A.; Tanase, C.; Pascu, G.-A.; Todoran, N. Recent Advances Regarding the Therapeutic Potential of Adapalene. Pharmaceuticals 2020, 13, 217. https://doi.org/10.3390/ph13090217

AMA Style

Rusu A, Tanase C, Pascu G-A, Todoran N. Recent Advances Regarding the Therapeutic Potential of Adapalene. Pharmaceuticals. 2020; 13(9):217. https://doi.org/10.3390/ph13090217

Chicago/Turabian Style

Rusu, Aura, Corneliu Tanase, Georgiana-Andreea Pascu, and Nicoleta Todoran. 2020. "Recent Advances Regarding the Therapeutic Potential of Adapalene" Pharmaceuticals 13, no. 9: 217. https://doi.org/10.3390/ph13090217

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop