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Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway

Institut de la Vision, Sorbonne Université, Inserm, CNRS, 17 rue Moreau, F-75012 Paris, France
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceuticals 2020, 13(7), 140; https://doi.org/10.3390/ph13070140
Received: 22 April 2020 / Revised: 19 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Targeting the Eph–ephrin System)
Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in pathological conditions including lesions in the heart, lung, or nervous system. They are also often misregulated in tumors. A wide range of molecular tools enabling the manipulation of the ephrin-A:EphA system are available, ranging from small molecules to peptides and genetically-encoded strategies. Their mechanism is either direct, targeting EphA receptors, or indirect through the modification of intracellular downstream pathways. Approaches enabling manipulation of ephrin-A:EphA forward signaling for the dissection of its signaling cascade, the investigation of its physiological roles or the development of therapeutic strategies are summarized here. View Full-Text
Keywords: ephrin; Eph; second messengers; peptides; vav guanine nucleotide exchange factor; Ephexin; cyclic guanosine monophosphate; cyclic adenosine monophosphate; calcium ephrin; Eph; second messengers; peptides; vav guanine nucleotide exchange factor; Ephexin; cyclic guanosine monophosphate; cyclic adenosine monophosphate; calcium
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Baudet, S.; Bécret, J.; Nicol, X. Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway. Pharmaceuticals 2020, 13, 140.

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