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Open AccessCommunication

Assessment of the Potential Skin Application of Plectranthus ecklonii Benth.

1
CBIOS—Universidade Lusófona Research Centre for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal
2
CERENA—Centre for Natural Resources and the Environment, Instituto Superior Técnico (IST), Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
3
iMed.ULisboa Research Institute for Medicines and Pharmaceutical Sciences, Universidade de Lisboa—Faculdade de Farmácia, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
4
IBEB, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisbon, Portugal
5
Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo BEB, 580 Lineu Prestes Av., Bloco 15, São Paulo/SP 05508-900, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceuticals 2020, 13(6), 120; https://doi.org/10.3390/ph13060120
Received: 13 May 2020 / Revised: 1 June 2020 / Accepted: 5 June 2020 / Published: 10 June 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
Plectranthus ecklonii Benth. has widespread ethnobotanical use in African folk medicine for its medicinal properties in skin conditions. In this study, two different basic formulations containing P. ecklonii extracts were prepared, one in an organic solvent and the other using water. The aqueous extract only contained rosmarinic acid (RA) at 2.02 mM, and the organic extract contained RA and parvifloron D at 0.29 and 3.13 mM, respectively. RA in aqueous solution permeated skin; however, in P. ecklonii organic extract, this was not detected. Thus, P. ecklonii aqueous extract was further studied and combined with benzophenone-4, which elevated the sun protection factor (SPF) by 19.49%. No significant cytotoxic effects were observed from the aqueous extract. The Staphylococcus epidermidis strain was used to determine a minimum inhibitory concentration (MIC) value of 10 µg·mL−1. The aqueous extract inhibited the activity of acetylcholinesterase by 59.14 ± 4.97%, and the IC50 value was 12.9 µg·mL−1. The association of the P. ecklonii extract with a UV filter substantially elevated its SPF efficacy. Following the multiple bioactivities of the extract and its active substances, a finished product could be claimed as a multifunctional cosmeceutical with broad skin valuable effects, from UV protection to antiaging action. View Full-Text
Keywords: Plectranthus ecklonii; parvifloron D; rosmarinic acid; in vitro permeation; sun protection factor; UV protection; antibacterial Plectranthus ecklonii; parvifloron D; rosmarinic acid; in vitro permeation; sun protection factor; UV protection; antibacterial
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MDPI and ACS Style

Nicolai, M.; Mota, J.; Fernandes, A.S.; Pereira, F.; Pereira, P.; P. Reis, C.; Robles Velasco, M.V.; Baby, A.R.; Rosado, C.; Rijo, P. Assessment of the Potential Skin Application of Plectranthus ecklonii Benth.. Pharmaceuticals 2020, 13, 120.

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