Next Article in Journal
Antibody Targeting of Eph Receptors in Cancer
Next Article in Special Issue
Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from Lycium shawii and Aloe vera: Evidence from In Silico Target Fishing and In Vitro Testing
Previous Article in Journal
Crosslinked Fibroin Nanoparticles: Investigations on Biostability, Cytotoxicity, and Cellular Internalization
Previous Article in Special Issue
Polyphenolic Profile and Varied Bioactivities of Processed Taiwanese Grown Broccoli: A Comparative Study of Edible and Non-Edible Parts
Open AccessArticle

Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv.

1
Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Ed. Polifunzionale, 87036 Rende (CS), Italy
2
Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
3
Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
4
Department of Chemistry, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(5), 87; https://doi.org/10.3390/ph13050087
Received: 14 March 2020 / Revised: 28 April 2020 / Accepted: 29 April 2020 / Published: 3 May 2020
Several epidemiological studies demonstrate that moderate (red) wine consumption may afford protection against cardiovascular diseases. Protection is ascribed to the biological activity of wine components, many of which, however, are discarded during winemaking. In vitro rat thoracic aorta rings contracted with phenylephrine or KCl were used to assess the vasorelaxant activity of extracts from wine pomaces (seeds and skins) of the Calabrian autochthonous grape variety Magliocco dolce (Arvino). NMR spectroscopy was used to ascertain their chemical composition. Data demonstrate that seed and skin, but not must, extracts are capable of relaxing vascular preparations in an endothelium-dependent manner, similarly to the red wine extract, due to the presence of comparable amounts of bioactive constituents. In rings pre-contracted with 20–30 mM KCl, only seed extracts showed a moderate relaxation. The most efficacious vasodilating extract (wine) showed a good antioxidant profile in both [(2,2-diphenyl-1-picrylhydrazyl)acid] radical (DPPH) and [2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] radical (ABTS) assays. In conclusion, winemaking from Magliocco dolce grape can provide potentially health-promoting by-products useful in cardiovascular disease management. View Full-Text
Keywords: vasoactivity; grape polyphenols; flavonoids; nitric oxide synthase; endothelium; TRPV1 vasoactivity; grape polyphenols; flavonoids; nitric oxide synthase; endothelium; TRPV1
Show Figures

Graphical abstract

MDPI and ACS Style

Carullo, G.; Ahmed, A.; Fusi, F.; Sciubba, F.; Di Cocco, M.E.; Restuccia, D.; Spizzirri, U.G.; Saponara, S.; Aiello, F. Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv.. Pharmaceuticals 2020, 13, 87.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop