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A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep

1
Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovy Blvd, Kemerovo 650002, Russia
2
Budker Institute of Nuclear Physics SB RAS, 11 akademika Lavrentieva Ave, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(5), 101; https://doi.org/10.3390/ph13050101
Received: 2 May 2020 / Revised: 14 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
The development of novel biodegradable vascular grafts of a small diameter (<6 mm) is an unmet clinical need for patients requiring arterial replacement. Here we performed a pre-clinical study of new small-caliber biodegradable vascular grafts using a sheep model of carotid artery implantation. The 4 mm diameter vascular grafts were manufactured using a mix of polyhydroxybutyrate/valerate and polycaprolactone supplemented with growth factors VEGF, bFGF and SDF-1α (PHBV/PCL-GFmix) and additionally modified by a polymer hydrogel coating with incorporation of drugs heparin and iloprost (PHBV/PCL-GFmixHep/Ilo). Animals with carotid artery autograft implantation and those implanted with clinically used GORE-TEX® grafts were used as control groups. We observed that 24 h following surgery, animals with carotid artery autograft implantation showed 87.5% patency, while all the PHBV/PCL-GFmix and GORE-TEX® grafts displayed thrombosis. PHBV/PCL-GFmixHep/Ilo grafts demonstrated 62.5% patency 24 h following surgery and it had remained at 50% 1 year post-operation. All the PHBV/PCL grafts completely degraded less than 1 year following surgery and were replaced by de novo vasculature without evidence of calcification. On the other hand, GORE-TEX® grafts displayed substantial amounts of calcium deposits throughout graft tissues. Thus, here we report a potential clinical usefulness of PHBV/PCL grafts upon their additional modification by growth factors and drugs to promote endothelialization and reduce thrombogenicity. View Full-Text
Keywords: biodegradable vascular graft; polycaprolactone; carotid artery implantation; sheep; pre-clinical study; heparin; iloprost; VEGF; bFGF; SDF-1α biodegradable vascular graft; polycaprolactone; carotid artery implantation; sheep; pre-clinical study; heparin; iloprost; VEGF; bFGF; SDF-1α
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Antonova, L.V.; Mironov, A.V.; Yuzhalin, A.E.; Krivkina, E.O.; Shabaev, A.R.; Rezvova, M.A.; Tkachenko, V.O.; Khanova, M.Y.; Sergeeva, T.Y.; Krutitskiy, S.S.; Barbarash, L.S. A Brief Report on an Implantation of Small-Caliber Biodegradable Vascular Grafts in a Carotid Artery of the Sheep. Pharmaceuticals 2020, 13, 101.

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