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Open AccessArticle

Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets

1
Centro Militar de Farmacia de la Defensa. Carretera M-609 de Miraflores, Km 34, Colmenar Viejo, 28770 Madrid, Spain
2
Unidad Docente de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, Spain
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(5), 100; https://doi.org/10.3390/ph13050100
Received: 18 April 2020 / Revised: 8 May 2020 / Accepted: 14 May 2020 / Published: 18 May 2020
(This article belongs to the Section Pharmaceutical Technology)
This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies. View Full-Text
Keywords: loperamide hydrochloride; orodispersible tablet; physicochemical characterization loperamide hydrochloride; orodispersible tablet; physicochemical characterization
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MDPI and ACS Style

Alejandro, B.; Guillermo, T.; Ángeles, P.M. Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. Pharmaceuticals 2020, 13, 100.

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