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The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

1
Department of Biomedical and Biotechnological Sciences, Section of Pharmacology University of Catania, 95123 Catania, Italy
2
Ph.D. Program in Biotechnologies, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
3
Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(4), 60; https://doi.org/10.3390/ph13040060
Received: 16 March 2020 / Revised: 27 March 2020 / Accepted: 29 March 2020 / Published: 1 April 2020
(This article belongs to the Collection Old Pharmaceuticals with New Applications)
Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the near future. Hence, the need for therapeutic alternatives to the current available treatments that, although various, do not guarantee a rapid and definite reparative process, appears necessary. We here analyzed current treatments for wound healing, but mainly focused the attention on few classes of drugs that are already in the market with different indications, but that have shown in preclinical and few clinical trials the potentiality to be used in the treatment of impaired wound healing. In particular, repurposing of the antiglycemic agents dipeptidylpeptidase 4 (DPP4) inhibitors and metformin, but also, statins and phenyotin have been analyzed. All show encouraging results in the treatment of chronic wounds, but additional, well designed studies are needed to allow these drugs access to the clinics in the therapy of impaired wound healing. View Full-Text
Keywords: wound closure; diabetic foot ulcer; DPP4 inhibitor; metformin; phenytoin; statins; drug repurposing wound closure; diabetic foot ulcer; DPP4 inhibitor; metformin; phenytoin; statins; drug repurposing
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Spampinato, S.F.; Caruso, G.I.; De Pasquale, R.; Sortino, M.A.; Merlo, S. The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs. Pharmaceuticals 2020, 13, 60.

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