Next Article in Journal
Quality-by-Design Is a Tool for Quality Assurance in the Assessment of Enantioseparation of a Model Active Pharmaceutical Ingredient
Next Article in Special Issue
Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin
Previous Article in Journal
Bromo-Cyclobutenaminones as New Covalent UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors
Previous Article in Special Issue
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 13
Issue 11
10.3390/ph13110363
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex

by
Consolacion Garcia-Contreras
1,
Marta Vazquez-Gomez
2,3,
José Luis Pesantez-Pacheco
1,4,
Ana Heras-Molina
1,
Teresa Encinas
2,
Susana Astiz
1 and
Antonio Gonzalez-Bulnes
1,2,*
1
SGIT-INIA, Ctra. De La Coruña Km. 7,5, 29040 Madrid, Spain
2
Faculty of Veterinary Medicine, UCM, Ciudad Universitaria s/n., 28040 Madrid, Spain
3
Facultat de Veterinària, Universitat Autònoma de Barcelona. Edifici V, Trav. dels Turons, 08193 Bellaterra, Spain
4
Faculty of Agricultural Sciences, School of Veterinary Medicine and Zootechnics, University of Cuenca, Avda. Doce de Octubre, 010220 Cuenca, Ecuador
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(11), 363; https://doi.org/10.3390/ph13110363
Submission received: 13 October 2020 / Revised: 31 October 2020 / Accepted: 3 November 2020 / Published: 4 November 2020
(This article belongs to the Special Issue Metformin: Mechanism and Application 2022)
Browse Figures
Versions Notes

Abstract

Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses’ developmental competence. There is no data on the duration of the effect of this treatment from the prenatal up to the postnatal stages. Therefore, the present trial aimed at determining the impact of metformin treatment on the offspring neonatal traits and early postnatal development (i.e., during lactation) using an in vivo swine model. The results support that maternal metformin treatment during pregnancy induces protective changes in body shape and composition of the progeny (i.e., larger head size and body length at birth and higher total viscera weight at weaning). However, there were also major effects of the offspring sex (smaller corpulence in females and lower relative weight of main viscerae in males), which should be considered for further preclinical studies and when even the current clinical application in women affected by PCOS or diabetes is implemented.
Keywords: intrauterine growth restriction; metformin; pregnancy; swine model intrauterine growth restriction; metformin; pregnancy; swine model

Share and Cite

MDPI and ACS Style

Garcia-Contreras, C.; Vazquez-Gomez, M.; Pesantez-Pacheco, J.L.; Heras-Molina, A.; Encinas, T.; Astiz, S.; Gonzalez-Bulnes, A. The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex. Pharmaceuticals 2020, 13, 363. https://doi.org/10.3390/ph13110363

AMA Style

Garcia-Contreras C, Vazquez-Gomez M, Pesantez-Pacheco JL, Heras-Molina A, Encinas T, Astiz S, Gonzalez-Bulnes A. The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex. Pharmaceuticals. 2020; 13(11):363. https://doi.org/10.3390/ph13110363

Chicago/Turabian Style

Garcia-Contreras, Consolacion, Marta Vazquez-Gomez, José Luis Pesantez-Pacheco, Ana Heras-Molina, Teresa Encinas, Susana Astiz, and Antonio Gonzalez-Bulnes. 2020. "The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex" Pharmaceuticals 13, no. 11: 363. https://doi.org/10.3390/ph13110363

APA Style

Garcia-Contreras, C., Vazquez-Gomez, M., Pesantez-Pacheco, J. L., Heras-Molina, A., Encinas, T., Astiz, S., & Gonzalez-Bulnes, A. (2020). The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex. Pharmaceuticals, 13(11), 363. https://doi.org/10.3390/ph13110363

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop