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Pharmaceuticals 2018, 11(4), 98; https://doi.org/10.3390/ph11040098

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

1,2,* and 1,2
1
Maurice Müller Laboratories, Department of Biomedical Research, University of Bern, 3008 Bern, Switzerland
2
University Clinic of Visceral Surgery and Medicine, Inselspital, 3010 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Received: 12 September 2018 / Revised: 30 September 2018 / Accepted: 2 October 2018 / Published: 5 October 2018
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host–microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host–microbe interactions in the context of human health and disease. View Full-Text
Keywords: iron; gut microbiota; iron supplementation; iron transporters; mucosal immunity; SCFA; intestinal inflammation; inflammatory bowel disease (IBD); colorectal cancer iron; gut microbiota; iron supplementation; iron transporters; mucosal immunity; SCFA; intestinal inflammation; inflammatory bowel disease (IBD); colorectal cancer
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Yilmaz, B.; Li, H. Gut Microbiota and Iron: The Crucial Actors in Health and Disease. Pharmaceuticals 2018, 11, 98.

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