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Pharmaceuticals 2018, 11(4), 107; https://doi.org/10.3390/ph11040107

Influence of Iron on Bone Homeostasis

1
Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary
2
Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
Received: 1 September 2018 / Revised: 5 October 2018 / Accepted: 12 October 2018 / Published: 18 October 2018
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated. Iron overload as well as iron deficiency disrupt the delicate balance between bone destruction and production, via influencing osteoclast and osteoblast differentiation as well as activity. Iron overload as well as iron deficiency are accompanied by weakened bones, suggesting that balanced bone homeostasis requires optimal—not too low, not too high—iron levels. The goal of this review is to summarize our current knowledge about how imbalanced iron influence skeletal health. Better understanding of this complex process may help the development of novel therapeutic approaches to deal with the pathologic effects of altered iron levels on bone. View Full-Text
Keywords: bone homeostasis; iron overload; iron deficiency; osteoclast; osteoblast; osteoporosis bone homeostasis; iron overload; iron deficiency; osteoclast; osteoblast; osteoporosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Balogh, E.; Paragh, G.; Jeney, V. Influence of Iron on Bone Homeostasis. Pharmaceuticals 2018, 11, 107.

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