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Pharmaceuticals 2018, 11(4), 105; https://doi.org/10.3390/ph11040105

Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

1
School of Physical Therapy and Athletic Training, Pacific University, Hillsboro, OR 97116, USA
2
Biological Sciences Department, City College of San Francisco, San Francisco, CA 94112, USA
*
Author to whom correspondence should be addressed.
Received: 1 September 2018 / Revised: 8 October 2018 / Accepted: 12 October 2018 / Published: 15 October 2018
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Abstract

Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations. View Full-Text
Keywords: arthritis; osteoarthritis; rheumatoid arthritis; gout; TRPA1; TRPV1; TRP; transient receptor potential arthritis; osteoarthritis; rheumatoid arthritis; gout; TRPA1; TRPV1; TRP; transient receptor potential
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Galindo, T.; Reyna, J.; Weyer, A. Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis. Pharmaceuticals 2018, 11, 105.

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