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TRPM Family Channels in Cancer

Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, France
FONDATION ARC, 9 rue Guy Môquet 94830 Villejuif, France
Authors to whom correspondence should be addressed.
Pharmaceuticals 2018, 11(2), 58;
Received: 25 April 2018 / Revised: 28 May 2018 / Accepted: 1 June 2018 / Published: 7 June 2018
Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy. View Full-Text
Keywords: TRPM channels; cancer; target; therapy TRPM channels; cancer; target; therapy
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MDPI and ACS Style

Hantute-Ghesquier, A.; Haustrate, A.; Prevarskaya, N.; Lehen’kyi, V. TRPM Family Channels in Cancer. Pharmaceuticals 2018, 11, 58.

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