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Pharmaceuticals 2018, 11(1), 17; https://doi.org/10.3390/ph11010017

Interactions Between Epilepsy and Plasticity

1
Cellular Neurobiology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico
2
Neurotransmission Biology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico
3
Development and Neural Regeneration Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico
Deceased, 2 August 2017.
*
Authors to whom correspondence should be addressed.
Received: 24 November 2017 / Revised: 1 February 2018 / Accepted: 6 February 2018 / Published: 7 February 2018
(This article belongs to the Special Issue Epilepsy and Neurodegeneration: Current Therapeutic Implications)
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Abstract

Undoubtedly, one of the most interesting topics in the field of neuroscience is the ability of the central nervous system to respond to different stimuli (normal or pathological) by modifying its structure and function, either transiently or permanently, by generating neural cells and new connections in a process known as neuroplasticity. According to the large amount of evidence reported in the literature, many stimuli, such as environmental pressures, changes in the internal dynamic steady state of the organism and even injuries or illnesses (e.g., epilepsy) may induce neuroplasticity. Epilepsy and neuroplasticity seem to be closely related, as the two processes could positively affect one another. Thus, in this review, we analysed some neuroplastic changes triggered in the hippocampus in response to seizure-induced neuronal damage and how these changes could lead to the establishment of temporal lobe epilepsy, the most common type of focal human epilepsy. View Full-Text
Keywords: seizures; hippocampus; granular cells; plasticity; epilepsy seizures; hippocampus; granular cells; plasticity; epilepsy
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Jarero-Basulto, J.J.; Gasca-Martínez, Y.; Rivera-Cervantes, M.C.; Ureña-Guerrero, M.E.; Feria-Velasco, A.I.; Beas-Zarate, C. Interactions Between Epilepsy and Plasticity. Pharmaceuticals 2018, 11, 17.

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