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Modelling a Peroxidase-based Optical Biosensor

Department of Software Engineering, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania
Institute of Mathematics and Informatics, Akademijos 4, LT-08663 Vilnius, Lithuania
Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Sauletekio al. 11, LT-10223 Vilnius, Lithuania
Author to whom correspondence should be addressed.
Sensors 2007, 7(11), 2723-2740;
Received: 8 October 2007 / Accepted: 9 November 2007 / Published: 14 November 2007
(This article belongs to the Special Issue Optical Biosensors)
PDF [289 KB, uploaded 21 June 2014]


The response of a peroxidase-based optical biosensor was modelled digitally.A mathematical model of the optical biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments, an enzyme layerand an outer diffusion layer. The digital simulation was carried out using finite differencetechnique. The influence of the substrate concentration as well as of the thickness of both theenzyme and diffusion layers on the biosensor response was investigated. Calculations showedcomplex kinetics of the biosensor response, especially at low concentrations of the peroxidaseand of the hydrogen peroxide. View Full-Text
Keywords: optical biosensor; peroxidase; modelling; simulation. optical biosensor; peroxidase; modelling; simulation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Baronas, R.; Gaidamauskait˙e, E.; Kulys, J. Modelling a Peroxidase-based Optical Biosensor. Sensors 2007, 7, 2723-2740.

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