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Volume 23
Issue 9
10.3390/s23094541
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Communication

Miniaturization of an Osmotic Pressure-Based Glucose Sensor for Continuous Intraperitoneal and Subcutaneous Glucose Monitoring by Means of Nanotechnology

by
Andreas Pfützner
1,2,3,4,5,*,
Barbora Tencer
1,
Boris Stamm
2,
Mandar Mehta
2,
Preeti Sharma
2,
Rustam Gilyazev
2,
Hendrick Jensch
3,
Nicole Thomé
3 and
Michael Huth
6
1
Lifecare AS, 5058 Bergen, Norway
2
Lifecare Nanobiosensors GmbH, 55128 Mainz, Germany
3
Lifecare Laboratories GmbH, 55128 Mainz, Germany
4
Pfützner Science & Health Institute, 55128 Mainz, Germany
5
Institute for Internal Medicine and Laboratory Medicine, University for Digital Technologies in Medicine & Dentistry, 9516 Wiltz, Luxembourg
6
Institute of Physics, Goethe-Universität, 60323 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
Sensors 2023, 23(9), 4541; https://doi.org/10.3390/s23094541
Submission received: 20 March 2023 / Revised: 2 May 2023 / Accepted: 3 May 2023 / Published: 7 May 2023
(This article belongs to the Section Sensors Development)
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Abstract

The Sencell sensor uses glucose-induced changes in an osmotic pressure chamber for continuous glucose measurement. A final device shall have the size of a grain of rice. The size limiting factor is the piezo-resistive pressure transducers inside the core sensor technology (resulting chamber volume: 70 µL. To achieve the necessary miniaturization, these pressure transducers were replaced by small (4000 × 400 × 150 nm³) nano-granular tunneling resistive (NTR) pressure sensors (chamber volume: 750 nL). For benchmark testing, we filled the miniaturized chamber with bovine serum albumin (BSA, 1 mM) and exposed it repeatedly to distilled water followed by 1 mM BSA solution. Thereafter, we manufactured sensors with glucose testing chemistry (ConcanavalinA/dextran) and investigated sensor performance with dynamic glucose changes between 0 and 300 mg/dL. Evaluation of the miniaturized sensors resulted in reliable pressure changes, both in the BSA benchmark experiment (30–35 mBar) and in the dynamic in vitro continuous glucose test (40–50 mBar). These pressure results were comparable to similar experiments with the previous larger in vitro sensors (30–50 mBar). In conclusion, the NTR pressure sensor technology was successfully employed to reduce the size of the core osmotic pressure chamber by more than 95% without loss in the osmotic pressure signal.
Keywords: continuous glucose monitoring; osmotic pressure; NTR sensor; FEBID; implantable glucose sensor continuous glucose monitoring; osmotic pressure; NTR sensor; FEBID; implantable glucose sensor

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MDPI and ACS Style

Pfützner, A.; Tencer, B.; Stamm, B.; Mehta, M.; Sharma, P.; Gilyazev, R.; Jensch, H.; Thomé, N.; Huth, M. Miniaturization of an Osmotic Pressure-Based Glucose Sensor for Continuous Intraperitoneal and Subcutaneous Glucose Monitoring by Means of Nanotechnology. Sensors 2023, 23, 4541. https://doi.org/10.3390/s23094541

AMA Style

Pfützner A, Tencer B, Stamm B, Mehta M, Sharma P, Gilyazev R, Jensch H, Thomé N, Huth M. Miniaturization of an Osmotic Pressure-Based Glucose Sensor for Continuous Intraperitoneal and Subcutaneous Glucose Monitoring by Means of Nanotechnology. Sensors. 2023; 23(9):4541. https://doi.org/10.3390/s23094541

Chicago/Turabian Style

Pfützner, Andreas, Barbora Tencer, Boris Stamm, Mandar Mehta, Preeti Sharma, Rustam Gilyazev, Hendrick Jensch, Nicole Thomé, and Michael Huth. 2023. "Miniaturization of an Osmotic Pressure-Based Glucose Sensor for Continuous Intraperitoneal and Subcutaneous Glucose Monitoring by Means of Nanotechnology" Sensors 23, no. 9: 4541. https://doi.org/10.3390/s23094541

APA Style

Pfützner, A., Tencer, B., Stamm, B., Mehta, M., Sharma, P., Gilyazev, R., Jensch, H., Thomé, N., & Huth, M. (2023). Miniaturization of an Osmotic Pressure-Based Glucose Sensor for Continuous Intraperitoneal and Subcutaneous Glucose Monitoring by Means of Nanotechnology. Sensors, 23(9), 4541. https://doi.org/10.3390/s23094541

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