Development of a New Voltammetric Method for Aceclofenac Determination on Glassy Carbon Electrode Modified with Hierarchical Nanocomposite
Abstract
:1. Introduction
2. Experimental
2.1. Apparatus
2.2. Chemicals and Glassware
2.3. Sample Preparation
2.3.1. Tablets
2.3.2. Lyophilizate Urine
2.3.3. Plasma
2.4. Fabrication of the eCNF/CNT/NiCo-GCE Sensor
2.4.1. Preparation of the Nanocomposite
Electrospinning
Thermal Treatment
2.4.2. Modification Process
2.5. Measurement Procedure
- Cleaning of the GCE surface: E = 1102 mV; t = 3 s;
- Accumulation: Eacc = 500 mV; tacc = 20 s;
- Rest period: 3 s;
- Registration of ACL voltammograms in the potential range: 500–1100 mV.
3. Results
3.1. Sensor Characterization
3.1.1. Volume of Modifier
3.1.2. Repeatability and Reproducibility
3.1.3. Stability of Sensor
3.2. Aceclofenac Behavior on the Surface of eCNF/CNT/NiCo-GCE
The Mechanism of the Electrochemical Reaction
3.3. Supporting Electrolyte Optimization
3.3.1. The Type of Supporting Electrolyte
3.3.2. The Concentration of Supporting Electrolyte
3.4. DPV Parameters Optimization
3.5. Accumulation Potential and Time Optimization
3.6. Interferences Study
3.7. Analytical Performance
4. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Type of Working Electrode | LOD, nM | LOQ, nM | Reference |
---|---|---|---|
OH-MWCNT/CPE | 246 | Not specified | [10] |
CMCPE | 19.3 | Not specified | [11] |
EPG | Not specified | 70 | [12] |
MCPGE | 2.6 | Not specified | [13] |
eCNF/CNT/NiCo-GCE | 0.7 | 2.1 | This work |
Sample | ACL Added, mg | ACL Found ± s, mg, (Recovery, %) |
---|---|---|
Tablet a | 0 | 110 ± 4 |
100 | 220 ± 2 (103) | |
200 | 325 ± 7 (103) | |
Sample | ACL added, µM | ACL found ± s, µM, (recovery, %) |
Urine diluted 20× | 0 | ND |
0.2 | 0.19 ± 0.01 (98) | |
0.4 | 0.39 ± 0.02 (99) | |
Urine diluted 10× | 0 | ND |
0.2 | 0.21 ± 0.01 (105) | |
0.4 | 0.42 ± 0.03 (105) | |
Plasma diluted 33× | 0 | ND |
0.2 | 0.19 ± 0.02 (98) | |
0.4 | 0.42 ± 0.03 (105) | |
Plasma diluted 20× | 0 | ND |
0.3 | 0.29 ± 0.02 (98) | |
0.6 | 0.63 ± 0.05 (104) |
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Górska, A.; Paczosa-Bator, B.; Gaidukevič, J.; Piech, R. Development of a New Voltammetric Method for Aceclofenac Determination on Glassy Carbon Electrode Modified with Hierarchical Nanocomposite. Sensors 2022, 22, 8954. https://doi.org/10.3390/s22228954
Górska A, Paczosa-Bator B, Gaidukevič J, Piech R. Development of a New Voltammetric Method for Aceclofenac Determination on Glassy Carbon Electrode Modified with Hierarchical Nanocomposite. Sensors. 2022; 22(22):8954. https://doi.org/10.3390/s22228954
Chicago/Turabian StyleGórska, Anna, Beata Paczosa-Bator, Justina Gaidukevič, and Robert Piech. 2022. "Development of a New Voltammetric Method for Aceclofenac Determination on Glassy Carbon Electrode Modified with Hierarchical Nanocomposite" Sensors 22, no. 22: 8954. https://doi.org/10.3390/s22228954