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Article

Monitoring Serum Spike Protein with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination

1
Departments of 1Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA
2
Biochemistry and Biophysics, University of Rochester, Rochester, NY 14627, USA
3
Optics, University of Rochester, Rochester, NY 14627, USA
4
Dermatology, University of Rochester, Rochester, NY 14627, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Andrea Cusano
Sensors 2021, 21(17), 5857; https://doi.org/10.3390/s21175857
Received: 31 July 2021 / Revised: 22 August 2021 / Accepted: 24 August 2021 / Published: 31 August 2021
(This article belongs to the Special Issue Novel Optical Sensors for Biomedical Application)
While mRNA vaccines have been well-studied in vitro and in animals prior to their use in the human population during the Covid-19 pandemic, their exact mechanisms of inducing immunity are still being elucidated. The large-scale collection of data necessary to fully understand these mechanisms, and their variability across heterogeneous populations, requires rapid diagnostic tests that accurately measure the various biomarkers involved in the immune response following vaccination. Recently, our lab developed a novel “Disposable Photonics” platform for rapid, label-free, scalable diagnostics that utilizes photonic ring resonator sensor chips combined with plastic micropillar cards able to provide passive microfluidic flow. Here, we demonstrate the utility of this system in confirming the presence of SARS-CoV-2 spike protein in the serum of recently vaccinated subjects, as well as tracking a post-vaccination rise in anti-SARS-CoV-2 antibodies. A maximum concentration in SARS-CoV-2 spike protein was detected one day after vaccination and was reduced below detectable levels within 10 days. This highlights the applicability of our rapid photonic sensor platform for acquiring the data necessary to understand vaccine mechanisms on a large scale, as well as individual patient responses to SARS-CoV-2 mRNA vaccines. View Full-Text
Keywords: ring resonator; SARS-CoV-2; passive microfluidics; vaccination ring resonator; SARS-CoV-2; passive microfluidics; vaccination
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MDPI and ACS Style

Cognetti, J.S.; Miller, B.L. Monitoring Serum Spike Protein with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination. Sensors 2021, 21, 5857. https://doi.org/10.3390/s21175857

AMA Style

Cognetti JS, Miller BL. Monitoring Serum Spike Protein with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination. Sensors. 2021; 21(17):5857. https://doi.org/10.3390/s21175857

Chicago/Turabian Style

Cognetti, John S., and Benjamin L. Miller. 2021. "Monitoring Serum Spike Protein with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination" Sensors 21, no. 17: 5857. https://doi.org/10.3390/s21175857

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