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Open AccessReview

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

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Department of Electrical and Computer Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA
2
Department of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(5), 1251; https://doi.org/10.3390/s20051251
Received: 7 February 2020 / Revised: 22 February 2020 / Accepted: 23 February 2020 / Published: 25 February 2020
(This article belongs to the Special Issue Bioimaging and Biosensing in Telemedicine)
Annual deaths in the U.S. attributed to diabetes are expected to increase from 280,210 in 2015 to 385,840 in 2030. The increase in the number of people affected by diabetes has made it one of the major public health challenges around the world. Better management of diabetes has the potential to decrease yearly medical costs and deaths associated with the disease. Non-invasive methods are in high demand to take the place of the traditional finger prick method as they can facilitate continuous glucose monitoring. Research groups have been trying for decades to develop functional commercial non-invasive glucose measurement devices. The challenges associated with non-invasive glucose monitoring are the many factors that contribute to inaccurate readings. We identify and address the experimental and physiological challenges and provide recommendations to pave the way for a systematic pathway to a solution. We have reviewed and categorized non-invasive glucose measurement methods based on: (1) the intrinsic properties of glucose, (2) blood/tissue properties and (3) breath acetone analysis. This approach highlights potential critical commonalities among the challenges that act as barriers to future progress. The focus here is on the pertinent physiological aspects, remaining challenges, recent advancements and the sensors that have reached acceptable clinical accuracy. View Full-Text
Keywords: glucose; non-invasive; diabetes; optical; absorption; scattering; Raman; polarimetry; bioimpedance; breath acetone glucose; non-invasive; diabetes; optical; absorption; scattering; Raman; polarimetry; bioimpedance; breath acetone
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Shokrekhodaei, M.; Quinones, S. Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone. Sensors 2020, 20, 1251.

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