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Article

Laser-Facilitated Additive Manufacturing Enables Fabrication of Biocompatible Neural Devices

1
Cluster of Excellence Hearing4All, 30627 Hannover, Germany
2
BioMaterial Engineering, Department of Otorhinolaryngology, Hannover Medical School, Carl Neuberg-Str. 1, 30625 Hannover, Germany
3
Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Nikolai-Fuchs-Str. 1, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(22), 6614; https://doi.org/10.3390/s20226614
Received: 30 September 2020 / Revised: 29 October 2020 / Accepted: 12 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Fabrication and Machining Technologies for Sensors)
Current personalized treatment of neurological diseases is limited by availability of appropriate manufacturing methods suitable for long term sensors for neural electrical activities in the brain. An additive manufacturing process for polymer-based biocompatible neural sensors for chronic application towards individualized implants is here presented. To process thermal crosslinking polymers, the developed extrusion process enables, in combination with an infrared (IR)-Laser, accelerated curing directly after passing the outlet of the nozzle. As a result, no additional curing steps are necessary during the build-up. Furthermore, the minimal structure size can be achieved using the laser and, in combination with the extrusion parameters, provide structural resolutions desired. Active implant components fabricated using biocompatible materials for both conductive pathways and insulating cladding keep their biocompatible properties even after the additive manufacturing process. In addition, first characterization of the electric properties in terms of impedance towards application in neural tissues are shown. The printing toolkit developed enables processing of low-viscous, flexible polymeric thermal curing materials for fabrication of individualized neural implants. View Full-Text
Keywords: additive manufacturing; medical grade silicone rubber; IR curing; biocompatibility; impedance; electrophysiology; neural implant; ECoG; medical rapid prototyping additive manufacturing; medical grade silicone rubber; IR curing; biocompatibility; impedance; electrophysiology; neural implant; ECoG; medical rapid prototyping
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MDPI and ACS Style

Behrens, A.; Stieghorst, J.; Doll, T.; Froriep, U.P. Laser-Facilitated Additive Manufacturing Enables Fabrication of Biocompatible Neural Devices. Sensors 2020, 20, 6614. https://doi.org/10.3390/s20226614

AMA Style

Behrens A, Stieghorst J, Doll T, Froriep UP. Laser-Facilitated Additive Manufacturing Enables Fabrication of Biocompatible Neural Devices. Sensors. 2020; 20(22):6614. https://doi.org/10.3390/s20226614

Chicago/Turabian Style

Behrens, Ailke, Jan Stieghorst, Theodor Doll, and Ulrich P. Froriep 2020. "Laser-Facilitated Additive Manufacturing Enables Fabrication of Biocompatible Neural Devices" Sensors 20, no. 22: 6614. https://doi.org/10.3390/s20226614

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