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Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells

1
Department of Physics and Astronomy and Institute of Applied Physics, Seoul National University, Seoul 08826, Korea
2
Department of Environmental Toxicology and Monitoring, Hanoi University of Natural Resources and Environment, Hanoi 11916, Vietnam
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(13), 3680; https://doi.org/10.3390/s20133680
Received: 8 June 2020 / Revised: 27 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Section Chemical Sensors)
We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notably, this method also allowed us to quantitatively monitor the cell responses by agonists and antagonists of nAChRs. These results suggest that our ion-selective CNT-FET sensor has potential uses in biological and medical researches such as the monitoring of ion-channel activity and the screening of drugs. View Full-Text
Keywords: carbon nanotube field-effect transistor; ion-selective membrane; valinomycin; nicotinic acetylcholine receptor; ion channel carbon nanotube field-effect transistor; ion-selective membrane; valinomycin; nicotinic acetylcholine receptor; ion channel
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Cho, Y.; Pham Ba, V.A.; Jeong, J.-Y.; Choi, Y.; Hong, S. Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells. Sensors 2020, 20, 3680.

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