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Open AccessArticle

Numerical Modeling and Investigation of Amperometric Biosensors with Perforated Membranes

1
Department of Mechanical Engineering, Shahid Chamran University, Ahvaz 61355, Iran
2
Metamaterials for Mechanical, Biomechanical and Multiphysical Applications Research Group, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam
3
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam
4
Department of Mechanical Engineering, Shahid Bahonar University of Kerman, Kerman 76169-14111, Iran
5
Division of Processes, KTH Royal Institute of Technology, 114 28 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(10), 2910; https://doi.org/10.3390/s20102910
Received: 24 March 2020 / Revised: 13 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Amperometric Sensing)
The present paper aims to investigate the influence of perforated membrane geometry on the performance of biosensors. For this purpose, a 2-D axisymmetric model of an amperometric biosensor is analyzed. The governing equations describing the reaction-diffusion equations containing a nonlinear term related to the Michaelis–Menten kinetics of the enzymatic reaction are introduced. The partial differential governing equations, along with the boundary conditions, are first non-dimensionalized by using appropriate dimensionless variables and then solved in a non-uniform unstructured grid by employing the Galerkin Finite Element Method. To examine the impact of the hole-geometry of the perforated membrane, seven different geometries—including cylindrical, upward circular cone, downward circular cone, upward paraboloid, downward paraboloid, upward concave paraboloid, and downward concave paraboloid—are studied. Moreover, the effects of the perforation level of the perforated membrane, the filling level of the enzyme on the transient and steady-state current of the biosensor, and the half-time response are presented. The results of the simulations show that the transient and steady-state current of the biosensor are affected by the geometry dramatically. Thus, the sensitivity of the biosensor can be influenced by different hole-geometries. The minimum and maximum output current can be obtained from the cylindrical and upward concave paraboloid holes. On the other hand, the least half-time response of the biosensor can be obtained in the cylindrical geometry. View Full-Text
Keywords: amperometric biosensor; biosensor current; finite element method; half-time response; mathematical model amperometric biosensor; biosensor current; finite element method; half-time response; mathematical model
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MDPI and ACS Style

Hashem Zadeh, S.M.; Heidarshenas, M.; Ghalambaz, M.; Noghrehabadi, A.; Saffari Pour, M. Numerical Modeling and Investigation of Amperometric Biosensors with Perforated Membranes. Sensors 2020, 20, 2910.

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