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Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection

1
Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy
2
Istituto Nazionale Biostrutture e Biosistemi (INBB), Research Unit of Florence, Viale delle Medaglie d’Oro 305, 00136 Roma, Italy
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(14), 3097; https://doi.org/10.3390/s19143097
Received: 20 May 2019 / Revised: 1 July 2019 / Accepted: 10 July 2019 / Published: 13 July 2019
(This article belongs to the Special Issue Smart Electrochemical Screen-Printed Platforms)
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Abstract

In this work, we report the development of a simple and sensitive sensor based on graphite screen-printed electrodes (GSPEs) modified by a nanocomposite film for dopamine (DA) detection. The sensor was realized by electrodepositing polyaniline (PANI) and gold nanoparticles (AuNPs) onto the graphite working electrode. The sensor surface was fully characterized by means of the cyclic voltammetry (CV) technique using [Fe(CN)6]4−/3− and [Ru(NH3)6]2+/3+ as redox probes. The electrochemical behavior of the nanocomposite sensor towards DA oxidation was assessed by differential pulse voltammetry (DPV) in phosphate buffer saline at physiological pH. The sensor response was found to be linearly related to DA concentration in the range 1–100 μM DA, with a limit of detection of 0.86 μM. The performance of the sensor in terms of reproducibility and selectivity was also studied. Finally, the sensor was successfully applied for a preliminary DA determination in human serum samples. View Full-Text
Keywords: dopamine; conducting polymer; gold nanoparticles; serum; electrochemical dopamine; conducting polymer; gold nanoparticles; serum; electrochemical
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Selvolini, G.; Lazzarini, C.; Marrazza, G. Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection. Sensors 2019, 19, 3097.

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