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Open AccessArticle

Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model

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Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA
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Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Wayne State University School of Medicine, Detroit, MI 48201, USA
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EKSPLA USA, Bozeman, MT 59715, USA
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Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
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Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(12), 2815; https://doi.org/10.3390/s19122815
Received: 26 April 2019 / Revised: 13 June 2019 / Accepted: 16 June 2019 / Published: 24 June 2019
(This article belongs to the Special Issue Skin Sensors)
The marked increase in the incidence of melanoma coupled with the rapid drop in the survival rate after metastasis has promoted the investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation. View Full-Text
Keywords: photoacoustic imaging; cancer imaging; skin imaging; ultrasound; optical coherence tomography; melanoma; swine melanoma model photoacoustic imaging; cancer imaging; skin imaging; ultrasound; optical coherence tomography; melanoma; swine melanoma model
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Kratkiewicz, K.; Manwar, R.; Rajabi-Estarabadi, A.; Fakhoury, J.; Meiliute, J.; Daveluy, S.; Mehregan, D.; Avanaki, K.M. Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model. Sensors 2019, 19, 2815.

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