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Sensors 2018, 18(5), 1550; https://doi.org/10.3390/s18051550

Determination of Tumor Marker Carcinoembryonic Antigen with Biosensor Based on Optical Quantum Weak Measurements

1
Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China
2
Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
3
Department of Physics, Tsinghua University, Beijing 100084, China
4
Shenzhen Maternity & Child Healthcare Hospital, Shenzhen 518055, China
*
Authors to whom correspondence should be addressed.
Received: 24 April 2018 / Revised: 7 May 2018 / Accepted: 8 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Label-Free Biosensors)
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Abstract

A phase-sensitive weak measurement biosensor was proposed for the detection of carcinoembryonic antigen (CEA), one common category of tumor markers. The total internal reflection (TIR) at the interface of the prism without precious metal coating was exploited to introduce the phase delay between horizontal and vertical polarizations, which can be determined through the central wavelength shift of output spectra for the sensing of the refractive index of the sample. In the weak measurement analysis, the specific binding reaction of tumor markers with a refractive index change on the surface of the prism can be monitored in real time through the central wavelength shift. With the specific absorption measurement, the feasibility of this weak measurement-based biosensor was experimentally demonstrated. We provide a low cost and convenient approach for tumor marker detection. View Full-Text
Keywords: phase measurement; optical biosensor; weak measurement; total internal reflection phase measurement; optical biosensor; weak measurement; total internal reflection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Guan, T.; Wang, X.; Li, D.; Zhang, Y.; He, Y.; Shi, L.; Liu, Y.; Yang, Y.; Xu, Y.; Cui, R. Determination of Tumor Marker Carcinoembryonic Antigen with Biosensor Based on Optical Quantum Weak Measurements. Sensors 2018, 18, 1550.

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