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Sensors 2018, 18(4), 1217;

Glucose Sensor Using U-Shaped Optical Fiber Probe with Gold Nanoparticles and Glucose Oxidase

Department of Mechanical Engineering, National Kaohsiung University of Science and Technology, No. 415, Jiangong Rd., Sanmin Dist., Kaohsiung City 807, Taiwan
Department of Aeronautical and Mechanical Engineering, Air Force Academy, Academy, No. Sisou 1, Jieshou W. Road, Kaohsiung 820, Taiwan
Author to whom correspondence should be addressed.
Received: 15 March 2018 / Revised: 12 April 2018 / Accepted: 13 April 2018 / Published: 16 April 2018
(This article belongs to the Special Issue Selected Sensor Related Papers from ICI2017)
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In this study, we proposed a U-shaped optical fiber probe fabricated using a flame heating method. The probe was packaged in glass tube to reduce human factors during experimental testing of the probe as a glucose sensor. The U-shaped fiber probe was found to have high sensitivity in detecting the very small molecule. When the sensor was dipped in solutions with different refractive indexes, its wavelength or transmission loss changed. We used electrostatic self-assembly to bond gold nanoparticles and glucose oxidase (GOD) onto the sensor’s surface. The results over five cycles of the experiment showed that, as the glucose concentration increased, the refractive index of the sensor decreased and its spectrum wavelength shifted. The best wavelength sensitivity was 2.899 nm/%, and the linearity was 0.9771. The best transmission loss sensitivity was 5.101 dB/%, and the linearity was 0.9734. Therefore, the proposed U-shaped optical fiber probe with gold nanoparticles and GOD has good potential for use as a blood sugar sensor in the future. View Full-Text
Keywords: glucose sensor; glucose oxidase; gold nanoparticles; U-shape optical fiber glucose sensor; glucose oxidase; gold nanoparticles; U-shape optical fiber

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Chen, K.-C.; Li, Y.-L.; Wu, C.-W.; Chiang, C.-C. Glucose Sensor Using U-Shaped Optical Fiber Probe with Gold Nanoparticles and Glucose Oxidase. Sensors 2018, 18, 1217.

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