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Sensors 2018, 18(4), 1204; https://doi.org/10.3390/s18041204

From Protein Features to Sensing Surfaces

Independent Scientist, St. Gallen 9000, Switzerland
Received: 28 February 2018 / Revised: 8 April 2018 / Accepted: 12 April 2018 / Published: 15 April 2018
(This article belongs to the Special Issue Biosensing for Interfacial Science)
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Abstract

Proteins play a major role in biosensors in which they provide catalytic activity and specificity in molecular recognition. However, the immobilization process is far from straightforward as it often affects the protein functionality. Extensive interaction of the protein with the surface or significant surface crowding can lead to changes in the mobility and conformation of the protein structure. This review will provide insights as to how an analysis of the physico-chemical features of the protein surface before the immobilization process can help to identify the optimal immobilization approach. Such an analysis can help to preserve the functionality of the protein when on a biosensor surface. View Full-Text
Keywords: surface functionalization; biosensor functionalization; protein immobilization; protein structure analysis; protein immobilization surface functionalization; biosensor functionalization; protein immobilization; protein structure analysis; protein immobilization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Faccio, G. From Protein Features to Sensing Surfaces. Sensors 2018, 18, 1204.

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