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Aptamer-Modified Magnetic Beads in Biosensing

Institute of Technical Chemistry, Leibniz University of Hannover, Hannover 30167, Germany
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Sensors 2018, 18(4), 1041; https://doi.org/10.3390/s18041041
Received: 24 February 2018 / Revised: 21 March 2018 / Accepted: 26 March 2018 / Published: 30 March 2018
(This article belongs to the Special Issue Magnetic Materials Based Biosensors)
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Abstract

Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes. Moreover, aptamers facilitate novel sensing strategies based on their oligonucleotide nature that cannot be realized with conventional peptide-based ligands. Due to these benefits, the combination of aptamers and MBs was already used in various analytical applications which are summarized in this article. View Full-Text
Keywords: aptamer; magnetic beads; analytical applications; electrochemical assays; optical assays; point-of-care-testing aptamer; magnetic beads; analytical applications; electrochemical assays; optical assays; point-of-care-testing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Modh, H.; Scheper, T.; Walter, J.-G. Aptamer-Modified Magnetic Beads in Biosensing. Sensors 2018, 18, 1041.

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