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Sensors 2017, 17(9), 1935;

Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification

711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA
UES, Inc., 4401 Dayton-Xenia Road, Dayton, OH 45432, USA
Current address: Department of Chemistry and Center for Nanostructured Electronic Materials, University of Florida, Gainesville, FL 32611, USA
Authors to whom correspondence should be addressed.
Received: 7 July 2017 / Revised: 16 August 2017 / Accepted: 19 August 2017 / Published: 23 August 2017
(This article belongs to the Section Biosensors)
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In this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross reactivity to chemicals typically used as fillers in street formulations. Plasmonic sensor variation was shown to produce unique data fingerprints for each chemical analyzed, supporting the application of multivariate statistical techniques to annotate unknown samples by chemical similarity. Importantly, the assay takes less than fifteen minutes to run, and requires only a few micrograms of the material, making the proposed assay easily deployable in field operations. View Full-Text
Keywords: illicit drugs; plasmonic sensor; aptamer; gold nanoparticle; cross-reactive; colorimetric illicit drugs; plasmonic sensor; aptamer; gold nanoparticle; cross-reactive; colorimetric

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yoho, J.N.; Geier, B.; Grigsby, C.C.; Hagen, J.A.; Chávez, J.L.; Kelley-Loughnane, N. Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification. Sensors 2017, 17, 1935.

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