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Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers

Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230088, China
Victoria General Hospital and River Heights/Fort Garry Community Areas, Winnipeg, MB, R3T 2E8, Canada
Seven Oaks General Hospital, Winnipeg, MB, R2V 3M3, Canada
Authors to whom correspondence should be addressed.
These authors contributed equally.
Sensors 2017, 17(12), 2934;
Received: 28 October 2017 / Revised: 30 November 2017 / Accepted: 13 December 2017 / Published: 17 December 2017
(This article belongs to the Special Issue Sensors for Health Monitoring and Disease Diagnosis)
PDF [1323 KB, uploaded 17 December 2017]


Cardiovascular disease (CVD) and cancer are two leading causes of death worldwide. CVD and cancer share risk factors such as obesity and diabetes mellitus and have common diagnostic biomarkers such as interleukin-6 and C-reactive protein. Thus, timely and accurate diagnosis of these two correlated diseases is of high interest to both the research and healthcare communities. Most conventional methods for CVD and cancer biomarker detection such as microwell plate-based immunoassay and polymerase chain reaction often suffer from high costs, low test speeds, and complicated procedures. Recently, lab-on-a-chip (LoC)-based platforms have been increasingly developed for CVD and cancer biomarker sensing and analysis using various molecular and cell-based diagnostic biomarkers. These new platforms not only enable better sample preparation, chemical manipulation and reaction, high-throughput and portability, but also provide attractive features such as label-free detection and improved sensitivity due to the integration of various novel detection techniques. These features effectively improve the diagnostic test speed and simplify the detection procedure. In addition, microfluidic cell assays and organ-on-chip models offer new potential approaches for CVD and cancer diagnosis. Here we provide a mini-review focusing on recent development of LoC-based methods for CVD and cancer diagnostic biomarker measurements, and our perspectives of the challenges, opportunities and future directions. View Full-Text
Keywords: lab-on-a-chip; cardiovascular disease; cancer; biomarker; microfluidic; point-of-care lab-on-a-chip; cardiovascular disease; cancer; biomarker; microfluidic; point-of-care

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Wu, J.; Dong, M.; Santos, S.; Rigatto, C.; Liu, Y.; Lin, F. Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers. Sensors 2017, 17, 2934.

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