Next Article in Journal
Piezoelectric Active Humidity Sensors Based on Lead-Free NaNbO3 Piezoelectric Nanofibers
Previous Article in Journal
A MEMS Resonant Sensor to Measure Fluid Density and Viscosity under Flexural and Torsional Vibrating Modes
Previous Article in Special Issue
SVD-Based Technique for Interference Cancellation and Noise Reduction in NMR Measurement of Time-Dependent Magnetic Fields

Homogeneous Biosensing Based on Magnetic Particle Labels

Molecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, Austria
Fachbereich Physik, Philipps-Universität Marburg, Marburg 35037, Germany
Laboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, France
Institute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, Germany
Experimentalphysik, Universität des Saarlandes, Saarbrücken 66123, Germany
Author to whom correspondence should be addressed.
NABLA Lab, Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University for Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
Diagnostic and Interventional Radiology Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
Academic Editor: Andreas Hütten
Sensors 2016, 16(6), 828;
Received: 22 April 2016 / Revised: 30 May 2016 / Accepted: 1 June 2016 / Published: 6 June 2016
(This article belongs to the Special Issue Magnetic Sensor Device-Part 1)
The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation. View Full-Text
Keywords: biosensor; magnetic nanoparticle; homogeneous assay; magnetorelaxation; AC susceptibility; NMR; magnetic relaxation switch; asynchronous magnetorotation; magneto-optics; nanorod biosensor; magnetic nanoparticle; homogeneous assay; magnetorelaxation; AC susceptibility; NMR; magnetic relaxation switch; asynchronous magnetorotation; magneto-optics; nanorod
Show Figures

Figure 1

MDPI and ACS Style

Schrittwieser, S.; Pelaz, B.; Parak, W.J.; Lentijo-Mozo, S.; Soulantica, K.; Dieckhoff, J.; Ludwig, F.; Guenther, A.; Tschöpe, A.; Schotter, J. Homogeneous Biosensing Based on Magnetic Particle Labels. Sensors 2016, 16, 828.

AMA Style

Schrittwieser S, Pelaz B, Parak WJ, Lentijo-Mozo S, Soulantica K, Dieckhoff J, Ludwig F, Guenther A, Tschöpe A, Schotter J. Homogeneous Biosensing Based on Magnetic Particle Labels. Sensors. 2016; 16(6):828.

Chicago/Turabian Style

Schrittwieser, Stefan, Beatriz Pelaz, Wolfgang J. Parak, Sergio Lentijo-Mozo, Katerina Soulantica, Jan Dieckhoff, Frank Ludwig, Annegret Guenther, Andreas Tschöpe, and Joerg Schotter. 2016. "Homogeneous Biosensing Based on Magnetic Particle Labels" Sensors 16, no. 6: 828.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop