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Sensors 2015, 15(5), 10481-10510;

Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

3,* and 1,2,4,*
BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea
Department of Nanobiotechnology, Korea University of Science and Technology (UST), Daejeon 305-350, Korea
Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea
Department of Pathobiology, College of Veterinary Medicine Nursing & Allied Health (CVMNAH), Tuskegee University, Tuskegee, AL 36088, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Yeshaiahu Fainman
Received: 12 March 2015 / Revised: 24 April 2015 / Accepted: 28 April 2015 / Published: 5 May 2015
(This article belongs to the Special Issue Resonant Sensors and Sensor Fusion)
Full-Text   |   PDF [3192 KB, uploaded 5 May 2015]   |  


Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review. View Full-Text
Keywords: surface plasmon resonance; SPR; biosensor; SPR imaging; applications surface plasmon resonance; SPR; biosensor; SPR imaging; applications

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nguyen, H.H.; Park, J.; Kang, S.; Kim, M. Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications. Sensors 2015, 15, 10481-10510.

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