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Open AccessArticle

Simultaneous Imaging of Two Different Cancer Biomarkers Using Aptamer-Conjugated Quantum Dots

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, 270-701, Korea
Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, 404-834, Korea
Al-Jeraisy, Chair for DNA Research, Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Department of Nucleic Acids Research, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technological Applications, Alexandria 21934, Egypt
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Shinya Maenosono
Sensors 2015, 15(4), 8595-8604;
Received: 10 March 2015 / Revised: 6 April 2015 / Accepted: 9 April 2015 / Published: 13 April 2015
(This article belongs to the Special Issue Inorganic Nanoparticles as Biomedical Probes)
Studying gene expression profile in a single cancer cell is important because multiple genes are associated with cancer development. Quantum dots (QDs) have been utilized as biological probes for imaging and detection. QDs display specific optical and electrical properties that depend on their size that can be applied for imaging and sensing applications. In this study, simultaneous imaging of the cancer biomarkers, tenascin-C and nucleolin, was performed using two types of aptamer-conjugated QDs. The simultaneous imaging of these two different cancer markers in three cancer cell lines was reliable and cell line-specific. Current requirements for cancer imaging technologies include the need for simple preparation methods and the ability to detect multiple cancer biomarkers and evaluate their intracellular localizations. The method employed in this study is a feasible solution to these requirements. View Full-Text
Keywords: quantum dot; aptamer; tenascin-C; nucleolin quantum dot; aptamer; tenascin-C; nucleolin
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Lee, J.; Kang, H.J.; Jang, H.; Lee, Y.J.; Lee, Y.S.; Ali, B.A.; Al-Khedhairy, A.A.; Kim, S. Simultaneous Imaging of Two Different Cancer Biomarkers Using Aptamer-Conjugated Quantum Dots. Sensors 2015, 15, 8595-8604.

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