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Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM

1
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
2
Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
3
Graduate School of Informatics, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan
4
Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
5
Division of Multidisciplinary Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan
*
Author to whom correspondence should be addressed.
Present Address: Department of Life System, Institute of Technology and Science, Graduate School, Tokushima University, Tokushima 770-8506, Japan
Academic Editor: Alexander Star
Sensors 2015, 15(12), 31973-31986; https://doi.org/10.3390/s151229900
Received: 2 November 2015 / Revised: 8 December 2015 / Accepted: 11 December 2015 / Published: 18 December 2015
(This article belongs to the Section Biosensors)
Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo. View Full-Text
Keywords: chiral dendrimer; gadolinium; contrast agent; magnetic resonance imaging (MRI); quartz crystal microbalance (QCM); association constant (Ka) chiral dendrimer; gadolinium; contrast agent; magnetic resonance imaging (MRI); quartz crystal microbalance (QCM); association constant (Ka)
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Miyake, Y.; Ishikawa, S.; Kimura, Y.; Son, A.; Imai, H.; Matsuda, T.; Yamada, H.; Toshimitsu, A.; Kondo, T. Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM. Sensors 2015, 15, 31973-31986.

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