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Sensors 2015, 15(1), 1168-1181;

A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing

The Institute for Photonics and Advanced Sensing (IPAS) and ARC Centre of Excellence for Nanoscale Biophotonics (CNBP), the University of Adelaide, Adelaide SA 5005, Australia
University of South Australia, Adelaide SA 5000, Australia
Author to whom correspondence should be addressed.
Received: 2 October 2014 / Accepted: 31 December 2014 / Published: 9 January 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
Full-Text   |   PDF [2599 KB, uploaded 9 January 2015]


The platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing remote excitation and collection of the WGM signal, the fiber provides significant practical advantages such as an easy manipulation of the microresonator and the use of this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present the first demonstration of the use of this approach for biological sensing and evaluate its limitation in a sensing configuration deprived of liquid flow which is most likely to occur in an in vivo setting. We also demonstrate the ability of this sensing platform to be operated above its lasing threshold, enabling enhanced device performance. View Full-Text
Keywords: fiber optics sensors; biological sensors; microcavities; laser resonators fiber optics sensors; biological sensors; microcavities; laser resonators
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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François, A.; Reynolds, T.; Monro, T.M. A Fiber-Tip Label-Free Biological Sensing Platform: A Practical Approach toward In-Vivo Sensing. Sensors 2015, 15, 1168-1181.

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