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Sensors 2012, 12(7), 9530-9550;

Synthetic Biomimetic Membranes and Their Sensor Applications

Institute of Life Sciences and Resources & Department of Food Science and Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Department of Biological Engineering, Inha University, Incheon 402-751, Korea
Nano-Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon 305-343, Korea
Department of Mechanical Engineering, Inha University, Incheon 402-751, Korea
Biohybrid Systems Research Center, Inha University, Incheon 402-751, Korea
Author to whom correspondence should be addressed.
Received: 9 May 2012 / Revised: 5 June 2012 / Accepted: 16 June 2012 / Published: 11 July 2012
(This article belongs to the Special Issue Biochips)
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Synthetic biomimetic membranes provide biological environments to membrane proteins. By exploiting the central roles of biological membranes, it is possible to devise biosensors, drug delivery systems, and nanocontainers using a biomimetic membrane system integrated with functional proteins. Biomimetic membranes can be created with synthetic lipids or block copolymers. These amphiphilic lipids and polymers self-assemble in an aqueous solution either into planar membranes or into vesicles. Using various techniques developed to date, both planar membranes and vesicles can provide versatile and robust platforms for a number of applications. In particular, biomimetic membranes with modified lipids or functional proteins are promising platforms for biosensors. We review recent technologies used to create synthetic biomimetic membranes and their engineered sensors applications. View Full-Text
Keywords: biomimetic membranes; lipid bilayer; ion channel sensors biomimetic membranes; lipid bilayer; ion channel sensors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kim, Y.-R.; Jung, S.; Ryu, H.; Yoo, Y.-E.; Kim, S.M.; Jeon, T.-J. Synthetic Biomimetic Membranes and Their Sensor Applications. Sensors 2012, 12, 9530-9550.

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