3-([4-(Acetylamino)phenyl]methoxy-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic Acid

Round 1

Reviewer 1 Report

Forbes and coworkers have reported a method for synthesizing a derivative of  norcantharidine: 3-([4-(Acetylamino)phenyl]methoxy-1-Carbonyl)-7-oxabicy-2 clo[2.2.1]heptane-2-Carboxylic Acid which could serve as an inhibitor of PP5.

The compound is novel and a full characterization is included which fits with the structure of the compound.

This reviewer believes that this short note may be accepted for publications after minor revisions.

The authors don’t specify in the structure whether the endo product is obtained or the exo. In Scheme 1 is specified that the exo product is obtained. However, in Scheme 2 the stereochemistry is omitted. Therefore, the stereochemistry of the product should be specified.

Author Response

1.  Summary: Thank you very much for taking the time to review this manuscript. Please find the detailed response below and the corresponding revision in the re-submitted file.

2. Are all figures and tables clear and well-presented?  Can be improved 

3.  Point-by-point response to Comment and Suggestion for Authors:

Comment: The authors don’t specify in the structure whether the endo product is obtained or the exo. In Scheme 1 is specified that the exo product is obtained. However, in Scheme 2 the stereochemistry is omitted. Therefore, the stereochemistry of the product should be specified.

Response:  Scheme 2 has been revised indicating relative stereochemistry which is aligned with Scheme 1.  The relative stereochemistry is based upon the spectral data (experimental) and prior work (References 7 & 9). 

Author Response File: Author Response.docx